English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/204388
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Risk assessment of chlorinated paraffins in feed and food

AuthorsSchrenk, Dieter; Bignami, Margherita; Bodin, Laurent; Chipman, James Kevin; Del Mazo, Jesús ; Grasl-Kraupp, Bettina; Hogstrand, Christer; Hoogenboom, Laurentius (Ron); Leblanc, Jean-Charles; Nebbia, Carlo Stefano; Ntzani, Evangelia; Petersen, Annette; Sand, Salomon; Schwerdtle, Tanja; Vleminckx, Christiane; Wallace, Heather; Brüschweiler, Beat; Leonards, Pim; Rose, Martin; Binaglia, Marco; Horvath, Zsuzsanna; Bordajandi, Luisa R.; Nielsen, Elsa
KeywordsChlorinated paraffins
SCCP
MCCP
LCCP
Food
Feed
Risk assessment
Issue Date19-Dec-2019
PublisherJohn Wiley & Sons
CitationEFSA Journal 18(3):5991 (2020)
AbstractThe European Commission asked EFSA for a scientific opinion on the risks for animal and human health related to the presence of chlorinated paraffins in feed and food. The data for experimental animals were reviewed and the CONTAM Panel identified the liver, kidney and thyroid as the target organs for the SCCP and MCCP mixtures tested in repeated dose toxicity studies. Decreased pup survival and subcutaneous haematoma/haemorrhage were also identified as critical effects for an MCCP mixture. For the LCCP mixtures tested, the liver was identified as the target organ. The Panel selected as reference points a BMDL10 of 2.3 mg/kg bw per day for increased incidence of nephritis in male rats, and of 36 mg/kg bw per day for increased relative kidney weights in male and female rats for SCCPs and MCCPs, respectively. For LCCPs, a reference point relevant for humans could not be identified. Due to the limitations in the toxicokinetic and toxicological database, the Panel concluded that derivation of a health-based guidance value was not appropriate. Only limited data on the occurrence of SCCPs and MCCPs in some fish species were submitted to EFSA. No data were submitted for LCCPs. Thus, a robust exposure assessment and consequently a complete risk characterisation could not be performed. A preliminary risk characterisation based only on the consumption of fish was performed, and the calculated margins of exposure suggested no health concern for this limited scenario. The Panel noted that dietary exposure will be higher due to the contribution of CPs from other foods. The Panel was not able to identify reference points for farm animals, horses and companion animals. No occurrence data for feed were submitted to EFSA.Therefore, no risk characterisation could be performed for any of these animal species.
Description220 p.-4 fig.-37 tab.-15 fig. compl.-16 tab. compl.-2 tab. append.
Publisher version (URL)https://doi.org/10.2903/j.efsa.2020.5991
URIhttp://hdl.handle.net/10261/204388
DOI10.2903/j.efsa.2020.5991
E-ISSN1831-4732
Appears in Collections:(CIB) Artículos
Files in This Item:
File Description SizeFormat 
j_efsa_Schrenk_D_2020.pdf25,29 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.