Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/204352
Share/Export:
logo share SHARE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
DC FieldValueLanguage
dc.contributor.authorHerranz, Rosario-
dc.contributor.authorFueyo-González, Francisco-
dc.contributor.authorGonzález-Verdejo, Juan A.-
dc.contributor.authorOrte, Angel-
dc.contributor.authorFernández-Gutiérrez, Mar-
dc.date.accessioned2020-03-18T11:22:18Z-
dc.date.available2020-03-18T11:22:18Z-
dc.date.issued2019-04-03-
dc.identifier.citation6th-ECBS/LS-EuChemS 3-5 abril 2019-
dc.identifier.urihttp://hdl.handle.net/10261/204352-
dc.description.abstractThe 1,8-naphthalimide scaffold is found among the most fruitful structures in the design of fluorophores with application in the development of fluorescence biosensors, due to its favorable photophysical properties, such as strong absorption and emission, large Stokes shifts, and photostability[1]. Considering that introduction of a nitrogen atom into the 1,8-naphtalimide skeleton could red-shift the fluorescence emission and increase water solubility, we have recently studied the design, synthesis and photophysical properties of 8-methoxy-4,5-quinolimides[2]. The photophysical properties of both scaffolds depend on the attached substituents and can be tuned by chemical manipulation. We have synthesized and will communicate new naphthalimide (A) and quinolimide (B) derivatives with a dimethylaminoethyl chain at the imide nitrogen atom, which behave as macrophage fluorescence sensors. Depending on the nature of the R substituent, these fluorophores can be used to imagine either the macrophage cytoplasm or the nucleus. The nucleus sensors bind DNA as intercalants.-
dc.description.sponsorshipThe work was supported by the Spanish Ministerio de Economía y Competividad grants SAF2012-32209, FU2015-67284-R, CTQ2017-85658-R, and the CSIC grant 201580E07-
dc.languageeng-
dc.relationMINECO/ICTI2013-2016/BFU2015-67284-R-
dc.relationMICIU/ICTI2017-2020/CTQ2017-85658-R-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccess-
dc.titleNaphthalimide-Based Fluorescence Macrophage Sensors. Localization Selectivity through Substituent Chemical Manipulation-
dc.typecomunicación de congreso-
dc.date.updated2020-03-18T11:22:19Z-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)-
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
item.fulltextWith Fulltext-
item.openairetypecomunicación de congreso-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
Appears in Collections:(IQM) Comunicaciones congresos
(ICTP) Comunicaciones congresos
Files in This Item:
File Description SizeFormat
Naphthalimide-Based Fluorescence.pdf314,83 kBAdobe PDFThumbnail
View/Open
Show simple item record

Google ScholarTM

Check


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.