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Transmissible gastroenteritis coronavirus RNA-dependent RNA polymerase and nonstructural proteins 2, 3, and 8 are incorporated into viral particles

AuthorsNogales, Aitor ; Márquez-Jurado, Silvia ; Galán, Carmen ; Enjuanes Sánchez, Luis ; Almazán, Fernando
Issue DateJan-2012
PublisherAmerican Society for Microbiology
CitationJournal of Virology 86(2): 1261-1266 (2012)
AbstractCoronavirus replication and transcription are processes mediated by a protein complex, with the RNA-dependent RNA polymerase (RdRp) as a main component. Proteomic analysis of highly purified transmissible gastroenteritis virus showed the RdRp to be a component of the viral particles. This finding was confirmed by Western blotting, immunofluorescence, and immunoelectron microscopy analyses. Interestingly, the replicase nonstructural proteins 2, 3, and 8 colocalized with the RdRp in the viral factories and were also incorporated into the virions. © 2012, American Society for Microbiology.
Publisher version (URL)http://dx.doi.org/10.1128/JVI.06428-11
Identifiersdoi: 10.1128/JVI.06428-11
issn: 0022-538X
pmid: 22090122
Appears in Collections:(VICYT) Colección Especial COVID-19
(CNB) Artículos
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