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Analysis of nutrigenomic effects of flavanols: a systematic bioinformatic evaluation of flavanol-modulated gene expressions in cell models of cardiometabolic disease

AuthorsMassaro, Marika; Ruskovska, Tatjana; Pascual-Teresa, Sonia de ; Krga, Irena; Vanden Berghe, Wim; Kistanova, Elena; Mena, Pedro; Gonthier, Marie-Paule; Nunes dos Santos, Claudia; Gomes, Andreia; Scoditti, Egeria; Carluccio, Maria Annunziata; Combet, Emilie; Calabriso, Nadia; Arola Arnal, Anna; Muguerza Marquínez, Maria Begoña; Suárez Recio, Manuel; Bravo Vázquez, Francisca Isabel; Gibney, Eileen R.; Rodríguez-Mateos, Ana; Morand, Christine; Milenkovic, Dragan
Issue Date2019
Citation13th Congress of the International Society of Nutrigenetics/Nutrigenomics (2019)
Abstract[Introduction]: The role of flavanols in terms of gene regulation in various cell models relevant to cardiometabolic disease has never been systematically addressed. Therefore, we conducted a systematic literature search and comprehensive bioinformatic analysis of the genes which expression has been reported as affected by flavanols in the cells defining the cardiometabolic health (hepatocytes, adipocytes, endothelial, smooth muscle and immune cells), to decipher molecular mechanisms of action underlying their cardiometabolic health properties. [Methods]: Literature search was performed in PubMed and Web of Science using pre-defined criteria (pure compounds and metabolites, no extracts, physiologically relevant concentrations). Identified differentially expressed genes were analyzed by several bioinformatic tools including: MetaCore, GeneTrail2 (for access to KEGG and BioCarta databases), Metascape and OmicsNet. [Results]: Analysis of extracted data from the literature identified 54 differentially expressed genes at mRNA level. Gene network analysis revealed that these genes are involved in inflammation, immune response, cell adhesion, apoptosis and cell signaling. Deeper analysis of their functional roles revealed the pathways such as TNF signaling pathway, NF-kappa B signaling pathway, Leukocyte transendothelial migration and Cell adhesion molecules. Studied cell types respond differently on the flavanol exposure, but inflammatory response is a common mechanism. Transcriptional factors, such as PPARG, NFKB1, CREB1 or STAT3, and miRNAs such as mir-335-5p, mir-16-5p, mir-124-3p or mir-26b-5p have been identified as regulators of gene expression by flavanols. [Conclusions]: The results of this systematic analysis of nutrigenomic effects of flavanols will support the future setup of nutrigenetic studies to pave the way for individualized dietary recommendations.
DescriptionResumen del trabajo presentado al 13th Congress of the International Society of Nutrigenetics/Nutrigenomics (ISNN), celebrado en Cambridge (UK) del 12 al 13 de julio de 2019.
Appears in Collections:(ICTAN) Comunicaciones congresos
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