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Title

Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein

AuthorsWidjaja, Ivy; Wang, Chengbao; Haperen, Rien van; Gutierrez-Alvarez, Francisco J. ; Dieren, Brenda van; Okba, Nisreen M. A.; Stalin Raj, V.; Li, Wentao; Fernandez-Delgado, Raúl ; Grosveld, Frank; Kuppeveld, Frank J. M. van; Haagmans, Bart L.; Enjuanes Sánchez, Luis CSIC ORCID ; Drabek, Dubravka; Bosch, Berend Jan
KeywordsCoronavirus
MERS
Antibodies
Spike protein
Issue Date2019
PublisherTaylor & Francis
CitationEmerging Microbes and Infections 8(1): 516-530 (2019)
AbstractThe Middle-East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus that causes severe and often fatal respiratory disease in humans. Efforts to develop antibody-based therapies have focused on neutralizing antibodies that target the receptor binding domain of the viral spike protein thereby blocking receptor binding. Here, we developed a set of human monoclonal antibodies that target functionally distinct domains of the MERS-CoV spike protein. These antibodies belong to six distinct epitope groups and interfere with the three critical entry functions of the MERS-CoV spike protein: sialic acid binding, receptor binding and membrane fusion. Passive immunization with potently as well as with poorly neutralizing antibodies protected mice from lethal MERS-CoV challenge. Collectively, these antibodies offer new ways to gain humoral protection in humans against the emerging MERS-CoV by targeting different spike protein epitopes and functions.
Publisher version (URL)http://dx.doi.org/10.1080/22221751.2019.1597644
URIhttp://hdl.handle.net/10261/204200
DOI10.1080/22221751.2019.1597644
Identifiersdoi: 10.1080/22221751.2019.1597644
e-issn: 2222-1751
pmid: 30938227
Appears in Collections:(CNB) Artículos
(VICYT) Colección Especial COVID-19

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