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Título: | Insights into cancer and neurodegenerative diseases through selenoproteins and the connection with gut microbiota: current analytical methodologies |
Autor: | Arias Borrego, Ana; Callejón Leblic, Belén; Calatayud Arroyo, Marta CSIC ORCID; Gómez-Ariza, José Luis; Collado, María Carmen CSIC ORCID; García Barrera, Tamara | Palabras clave: | Cancer ICP-MS Metallomics Microbiota Neurodegenerative diseases Selenium Selenoproteins Speciation |
Fecha de publicación: | 18-sep-2019 | Editor: | Taylor & Francis | Citación: | Expert Review of Proteomics 16 (10): 805-814 (2019) | Resumen: | Introduction: Selenium plays many key roles in health especially in connection with cancer and neurodegenerative diseases. However, it needs to be appreciated that the essentiality/toxicity of selenium depends on both, a narrow range of concentration and the chemical specie involved. In this context, selenoproteins are essential biomolecules against these disorders, mainly due to its antioxidant action. To this end, analytical methodologies may allow identifying and quantifying individual selenospecies in human biofluids and tissues. Areas covered: This review focus on the role of selenoproteins in medicine, with special emphasis in cancer and neurodegenerative diseases, considering the possible link with gut microbiota. In particular, this article reviews the analytical techniques and procedures recently developed for the absolute quantification of selenoproteins and selenometabolites in human biofluids and tissues. Expert commentary: The beneficial role of selenium in human health has been extensively studied and reviewed. However, several challenges remain unsolved as discussed in this article: (i) speciation of selenium (especially selenoproteins) in cancer and neurodegenerative disease patients; (ii) supplementation of selenium in humans using functional foods and nutraceuticals; (iii) the link between selenium and selenoproteins expression and the gut microbiota and (iv) analytical methods and pitfalls for the absolute quantification of selenoproteins and selenometabolites. | Descripción: | This is the Author’s Original Manuscript of an article published by Taylor & Francis in Expert Review of Proteomics on 18 Sep 2019, available online: http://www.tandfonline.com/10.1080/14789450.2019.1664292 | Versión del editor: | https://doi.org/10.1080/14789450.2019.1664292 | URI: | http://hdl.handle.net/10261/204184 | DOI: | 10.1080/14789450.2019.1664292 | ISSN: | 1478-9450 |
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ExpertReviewProteo2019-Arias-Borrego.pdf | Artículo principal | 388,58 kB | Adobe PDF | Visualizar/Abrir |
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