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dc.contributor.authorFlores, Enrique-
dc.contributor.authorPicossi, Silvia-
dc.contributor.authorValladares, Ana-
dc.contributor.authorHerrero, Antonia-
dc.date.accessioned2020-03-12T09:48:21Z-
dc.date.available2020-03-12T09:48:21Z-
dc.date.issued2019-
dc.identifierdoi: 10.1016/j.bbagrm.2018.04.006-
dc.identifierissn: 1876-4320-
dc.identifier.citationBiochimica et Biophysica Acta - Gene Regulatory Mechanisms 1862: 673- 684 (2019)-
dc.identifier.urihttp://hdl.handle.net/10261/203683-
dc.description.abstractFilamentous, heterocyst-forming cyanobacteria are among the simplest multicellular systems in Nature. In the absence of combined nitrogen, the filaments consist of vegetative cells that fix CO2 through oxygenic photosynthesis and micro-oxic heterocysts specialized for the fixation of N2 in a proportion of about 10 to 1. The development of a heterocyst-containing filament involves differentiation of vegetative cells into heterocysts in a process that requires a distinct gene expression program. Two transcription factors are strictly required, NtcA and HetR. The CRP-family protein NtcA directly activates the expression of multiple genes during heterocyst differentiation – in some cases assisted by coactivators including HetR – and in mature heterocysts, whereas HetR is needed to build high NtcA levels in differentiating heterocysts and directly activates some particular genes. A few other regulators of gene expression participate at specific differentiation steps, and a specific transcription factor, CnfR, activates nif gene expression under the micro-oxic conditions of the heterocyst.-
dc.languageeng-
dc.publisherElsevier-
dc.relation.isversionofPostprint-
dc.rightsopenAccessen_EN
dc.titleTranscriptional regulation of development in heterocyst-forming cyanobacteria.-
dc.typeartículo-
dc.identifier.doihttp://dx.doi.org/10.1016/j.bbagrm.2018.04.006-
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.bbagrm.2018.04.006-
dc.embargo.terms2020-04-30-
dc.date.updated2020-03-12T09:48:22Z-
dc.relation.csic-
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