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Advantajes and disadvantajes of zebrafish as a model of inflammation

AuthorsNovoa, Beatriz ; Varela, Mónica ; Forn-Cuni, Gabriel ; Pereiro, Patricia ; Figueras Huerta, Antonio
Issue Date2019
Citation3rd International Symposium on Fish & Shellfish Immunology (2019)
AbstractZebrafish (Danio rerio), largely used as a model for studying developmental processes, has also emerged as a valuable system for modelling human disease. Zebrafish possesses a complex immune system comparable to those of mammalian models. Nevertheless, whole-genome duplication event and subfunction specialization of gene duplicates results in a more intricate relationship among the components implicated in the immune response and as a consequence in the inflammatory response. This is the case of the of the complement component c3 with 8 different genes in the zebrafish genome and different functions. This aspect, that could be considered an inconvenient, contrasts with the clear advantages that this model offers. We show how the real-time imaging and the use of the whole animal are excellent tools to visualize the in vivo interaction of a pathogen with the immune system. Also, we demonstrate how the genomic responses of adult zebrafish tissues can effectively reproduce the mammalian inflammatory process induced by acute endotoxin stress. Immune signalling has been well conserved throughout evolution and zebrafish and mammal genomic responses after lipopolysaccharide stimulation are highly correlated. Therefore, we confirm that zebrafish is an ideal model to study the basic mechanisms of inflammation and to model human inflammatory diseases
Description3rd International Symposium on Fish & Shellfish Immunology, June 16th-20th 2019, Las Palmas de Gran Canaria (Spain)
Appears in Collections:(IIM) Comunicaciones congresos
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