Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/203502
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dc.contributor.authorLebrón, José Antonioes_ES
dc.contributor.authorOstos, Francisco Josées_ES
dc.contributor.authorLópez-López, Manueles_ES
dc.contributor.authorMoyá, María Luisaes_ES
dc.contributor.authorKardell, O.es_ES
dc.contributor.authorSánchez, A.es_ES
dc.contributor.authorCarrasco, C. J.es_ES
dc.contributor.authorGarcía-Calderón, Clara B.es_ES
dc.contributor.authorRosado, Iván V.es_ES
dc.contributor.authorLópez-Cornejo, Pilares_ES
dc.date.accessioned2020-03-11T08:13:01Z-
dc.date.available2020-03-11T08:13:01Z-
dc.date.issued2019-03-01-
dc.identifier.citationColloids and Surfaces B: Biointerfaces 175: 116-125 (2019)es_ES
dc.identifier.issn0927-7765-
dc.identifier.urihttp://hdl.handle.net/10261/203502-
dc.description.abstractThe use of nanovectors in several medicinal treatments has reached a great importance in the last decade. Some drugs need to be protected to increase their lifetimes in the blood flow, to avoid degradation, to be delivered into target cells or to decrease their side effects. The goal of this work was to design and prepare nanovectors formed by novel surfactants derived from the [Ru(bpy)3]2+ complex. These amphiphilic molecules are assembled to form metallomicelles which can act as pharmaceutical agents and, at the same time, as nanovectors for several drugs. TEM images showed a structural transition from spherical to elongated micelles when the surfactant concentration increased. Fluorescence microscopy confirmed the internalization of these metallomicelles into diverse cell lines and cytotoxicity assays demonstrated specificity for some human cancer cells. The encapsulation of various antibiotics was carried out as well as a thorough study about the DNA condensation by the metallomicelles. To the best of our knowledge, applications of these metallomicelles have not been shown in the literature yet.es_ES
dc.description.sponsorshipThis work was supported by the Consejería de Educación y Ciencia de la Junta de Andalucía (Proyecto de Excelencia P12-FQM-1105, FQM-206 and FQM-274), the VI Plan Propio Universidad de Sevilla (2018/500) and the European Union (Feder Funds). The authors thank the University of Seville for the grant VPPI-US.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsclosedAccesses_ES
dc.subjectNanocarrieres_ES
dc.subjectMetallosurfactantes_ES
dc.subjectMetallomicellees_ES
dc.subjectInternalization into cellses_ES
dc.subjectDNA condensationes_ES
dc.titlePreparation and characterization of metallomicelles of Ru(II). Cytotoxic activity and use as vectores_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.colsurfb.2018.11.081-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://doi.org/10.1016/j.colsurfb.2018.11.081-
dc.contributor.funderJunta de Andalucíaes_ES
dc.contributor.funderUniversidad de Sevillaes_ES
dc.contributor.funderEuropean Commissiones_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/100009042es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011011es_ES
item.fulltextNo Fulltext-
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
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