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Título: | Down-regulation of Cdk1 activity in G1 coordinates the G1/S gene expression programme with genome replication |
Autor: | García-Blanco, Natalia CSIC; Moreno, Sergio CSIC ORCID | Palabras clave: | Cell cycle G1/S transcription MBF CDK inhibition Rum1 Ste9 Genomic instability, dNTPs Nitrogen, TORC2 Gad8 |
Fecha de publicación: | 24-ene-2019 | Editor: | Springer Nature | Citación: | Current Genetics 65: 685-690 (2019) | Resumen: | Cell division is regulated by cyclin-dependent kinases (Cdks) and requires the periodic activation and inactivation of transcription factors that generate waves of gene expression in different cell-cycle phases. In fission yeast, the MCB-binding transcription factor (MBF) is activated at the end of G1 and regulates the expression of a set of genes that encode for proteins involved in the G1/S transition and DNA replication. Here, we review the importance of controlling MBF by Cdk activity at the onset of S phase. Furthermore, we emphasize that MBF regulation by Cdk is particularly critical under conditions in which G1 is extended, such as in nitrogen-poor environments, where down-regulation of Cdk activity in G1 is crucial to generate a proper wave of MBF-dependent transcription at the end of G1, which is critical to promote a successful S phase. | Versión del editor: | http://dx.doi.org/10.1007/s00294-018-00926-y | URI: | http://hdl.handle.net/10261/203463 | DOI: | 10.1007/s00294-018-00926-y | Identificadores: | doi: 10.1007/s00294-018-00926-y e-issn: 1432-0983 issn: 0172-8083 |
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