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Título: | Replication fork barriers and topological barriers: progression of DNA replication relies on DNA topology ahead of forks |
Otros títulos: | Running Title: DNA replication and topology | Autor: | Schvartzman, Jorge Bernardo CSIC ORCID ; Hernandez, Pablo CSIC ; Krimer, Dora B. CSIC ORCID | Palabras clave: | DNA topology Replication Supercoiling Pre-catenation Two-dimensional agarose gel electrophoresis |
Fecha de publicación: | 1-mar-2020 | Editor: | John Wiley & Sons | Resumen: | During replication, the topology of DNA changes continuously in response to well‐known activities of DNA helicases, polymerases, and topoisomerases. However, replisomes do not always progress at a constant speed and can slow‐down and even stall at precise sites. The way these changes in the rate of replisome progression affect DNA topology is not yet well understood. The interplay of DNA topology and replication in several cases where progression of replication forks reacts differently to changes in DNA topology ahead is discussed here. It is proposed, there are at least two types of replication fork barriers: those that behave also as topological barriers and those that do not. Two‐Dimensional (2D) agarose gel electrophoresis is the method of choice to distinguish between these two different types of replication fork barriers. | Descripción: | 22 p.-5 fig. | Versión del editor: | https://doi.org/10.1002/bies.201900204 | URI: | http://hdl.handle.net/10261/203192 | DOI: | 10.1002/bies.201900204 | ISSN: | 0265-9247 | E-ISSN: | 1521-1878 |
Aparece en las colecciones: | (CIB) Artículos |
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Schvartzman-BioEssays_2020.pdf | Postprint | 1,18 MB | Adobe PDF | Visualizar/Abrir |
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