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Biogenic metallic nanoparticles. From microbiological biofactories to nanometric trojan horses

AuthorsGarcía-Martín, José Miguel ; Medina Cruz, David; Vernet Crua, Ada; Huttel, Yves ; Martínez-Orellana, Lidia ; González Sagardoy, María Ujué ; Cholula-Díaz, Jorge L.; Guisbiers, Gregory; Webster, Thomas J.
Issue Date2-Sep-2019
CitationEUROMAT (2019)
AbstractIntroduction/Purpose: Antimicrobial resistance to antibiotics and cancer and two of the main concerns that the healthcare system should face nowadays. Current drugs and antibiotic treatments are becoming ineffective or have plenty of drawbacks. Therefore, new alternatives are needed. Traditional synthesis of nanomaterials is subjected to several disadvantages, such as the production of toxic-by-products and harsh conditions. Green nanotechnology is presented as a suitable answer, allowing the generation of nanostructures in a cost-effective and environmentally-friendly approach. Methods: Pathogenic bacteria and human cells were used for the synthesis of metallic/metalloid nanoparticles: selenium (Se), gold (Au), palladium (Pd), platinum (Pt), gold-palladium (AuPd) and goldplatinum (AuPt). Bacteria and cells are cultured in the presence of metallic salts under standard conditions until the generation of nanoparticles, that is followed using microscopy and spectrophotometric techniques. Nanoparticles were used as antimicrobial and anticancer agents using colony counting unit assays and MTS assays, respectively, as well as extensively characterized in terms of composition, surface chemistry and morphology. Results: The nanomaterials were successfully used as biomedical agents, showing antimicrobial and anticancer properties, with no significant cytotoxic effect towards healthy human cells. Besides, they nanoparticles showed a selective behavior in their antimicrobial and anticancer effects, where nanoparticles made by the bacteria/human cell X were more efficient inhibiting the growth or the target bacteria/human cells X, while another target would show less inhibition. Besides, the production of nanoparticles in human cells was able to induce a transformation of the cell into what we called “zombie stage” or suspension, not being degraded by temporal, physical or chemical means. Conclusions: Microbiological agents are successfully used as a synthetic machine for the generation of metallic nanoparticles of different compositions with biomedical properties. Therefore, they are presented as a suitable approach for the synthesis of nanomaterials in a green fashion, overcoming the limitations of traditional nanotechnology
DescriptionTrabajo presentado al European Congress and Exhibition on Advanced Materials and Processes (EUROMAT), celebrado en Estocolmo (Suecia) del 1 al 5 de septiembre de 2019.
Appears in Collections:(ICMM) Comunicaciones congresos
(IMN-CNM) Comunicaciones congresos
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