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A Straightforward Synthesis of Functionalized cis-Perhydroisoquinolin-1-ones

AuthorsArioli, Federica; Pérez, Maria; Are, Celeste; Molins, Elies ; Bosch, Joan; Amat, Mercedes
Issue Date3-Feb-2019
AbstractBase-catalyzed annulation reactions of 5,6-dihydro-2(1H)-pyridones with Nazarov-type reagents are reported. The effect of the solvent polarity and the concentration of the reagents is studied. The process involves two successive Michael additions and stereoselectively provides functionalized cis-perhydroisoquinolin-1-ones.
Publisher version (URL)http://dx.doi.org/10.3390/molecules24030557
Appears in Collections:(ICMAB) Artículos
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