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Title

Reviewing the evidence on breast milk composition and immunological outcomes

AuthorsBoix Amorós, Alba; Collado, María Carmen ; Van't Land, Belinda; Calvert, Anna; Le Doare, Kirsty; Garssen, Johan; Hanna, Heather; Khaleva, Katerina; Peroni, Diego G.; Geddes, Donna T.; Kozyrskyj, Anita L.; Warner, John O.; Munblit, Daniel
KeywordsAntibiotics
Breast milk
Human milk
Immune active molecules
Immunological outcomes
Microbiome
Oligosaccharides
Vaccine response
Issue Date21-May-2019
PublisherOxford University Press
CitationNutrition Reviews 77(8): 541-556
AbstractA large number of biologically active components have been found in human milk (HM), and in both human and animal models, studies have provided some evidence suggesting that HM composition can be altered by maternal exposures, subsequently influencing health outcomes for the breastfed child. Evidence varies from the research studies on whether breastfeeding protects the offspring from noncommunicable diseases, including those associated with immunological dysfunction. It has been hypothesized that the conflicting evidence results from HM composition variations, which contain many immune active molecules, oligosaccharides, lactoferrin, and lysozyme in differing concentrations, along with a diverse microbiome. Determining the components that influence infant health outcomes in terms of both short- and long-term sequelae is complicated by a lack of understanding of the environmental factors that modify HM constituents and thereby offspring outcomes. Variations in HM immune and microbial composition (and the differing infantile responses) may in part explain the controversies that are evidenced in studies that aim to evaluate the prevalence of allergy by prolonged and exclusive breastfeeding. HM is a “mixture” of immune active factors, oligosaccharides, and microbes, which all may influence early immunological outcomes. This comprehensive review provides an in-depth overview of existing evidence on the studied relationships between maternal exposures, HM composition, vaccine responses, and immunological outcomes.
DescriptionThis is a pre-copyedited, author-produced version of an article accepted for publication in Nutrition Reviews following peer review. The version of record "Reviewing the evidence on breast milk composition and immunological outcomes. Boix-Amoros, Alba; Collado, Maria Carmen; Van't Land, Belinda; Calvert, Anna; Le Doare, Kirsty; Garssen, Johan; Hanna, Heather; Khaleva, katerina; Peroni, Diego G.; Geddes, Donna T.; Kozyrskyj, Anita L.; Warner, John O.; Munblit, Daniel. Nutrition Reviews August 2019; 77 (8): 541-556" is available online at:https://doi.org/10.1093/nutrit/nuz019
Publisher version (URL)https://doi.org/10.1093/nutrit/nuz019
URIhttp://hdl.handle.net/10261/203022
DOI10.1093/nutrit/nuz019
ISSN0029-6643
Appears in Collections:(IATA) Artículos
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