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A collection of integration-free iPSCs derived from Parkinson's disease patients carrying mutations in the GBA1 gene

AuthorsRodríguez-Traver, E.; Díaz-Guerra, E.; Rodríguez, C.; Fernández, P. CSIC; Arenas, F.; Araúzo-Bravo, Marcos J.; Orera, M.; Kulisevsky, J.; Moratalla, Rosario CSIC ORCID ; Vicario, C.
Issue Date2019
CitationStem Cell Research 38 (2019)
AbstractMutations in the GBA1 gene, which encodes the lysosomal enzyme Glucocerebrosidase1 are major risk factors for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). We have generated induced pluripotent stem cells (iPSCs) from fibroblasts of four PD patients carrying the N370S/wt or the L444P/wt heterozygous mutations in GBA1. The iPSCs presented a normal morphology, expressed endogenous pluripotency markers and could be differentiated into endodermal, mesodermal and ectodermal cells. These iPSCs were free from Sendai viral vectors and reprogramming factors, had a normal karyotype and maintained the original GBA1 genotype.
Publisher version (URL)http://dx.doi.org/10.1016/j.scr.2019.101482
Identifiersdoi: 10.1016/j.scr.2019.101482
issn: 1876-7753
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