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Stearoyl-CoA desaturase (scd1a) is epigenetically regulated by broodstock nutrition in gilthead sea bream (Sparus aurata)

AuthorsPerera, Erick; Turkmen, Serhat; Simó-Mirabet, Paula; Zamorano, María J.; Xu, Hanlin; Naya-Català, Fernando; Izquierdo, Marisol; Pérez-Sánchez, Jaume
Issue Date7-Oct-2019
CitationAquaculture Europe 2019
AbstractHigh substitution of fish oil (FO) by vegetable oils (VO) in aquafeeds is still a challenge for marine fish. VOs have low content of n-3 LC-PUFA such as EPA and DHA, and instead, they are rich in fatty acids (FA) such as ALA and LA. High VO feeding leads to increased hepatic fat accumulation in gilthead sea bream (Sparus aurata) and other fish species, increasing the risk of steatosis. Different studies in fish have provided evidence of the effect of broodstock nutrition on the lipid metabolism of the progeny (e.g., Izquierdo et al., 2015; Turkmen et al., 2017). In higher vertebrates, enriching maternal diet with ALA prevented fatty liver in the offspring (Hollander et al., 2014) by decreasing both SCD1 and FADS2 gene expression (Leikin-Frenkel et al., 2017). We used a ‘control’ and an ‘ALA-rich’ diet to study the effect of parent’s nutrition on the promoter methylation and gene expression of fads2 and scd1a in S. aurata offspring.
DescriptionTrabajo presentado en Aquaculture Europe 2019, celebrado en Berlín (Alemania), del 7 al 10 de octubre de 2019
Appears in Collections:(IATS) Comunicaciones congresos
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