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Generation of a human iPS cell line (CABi003-A) from a patient with age-related macular degeneration carrying the CFH Y402H polymorphism

AuthorsGarcía-Delgado, Ana B.; Calado, Sofia M.; Valdés-Sánchez, María Lourdes; Montero-Sánchez, Adoración; Ponte-Zuñiga, Beatriz; Cerda, Berta de la ; Bhattacharya, Shom Shanker ; Díaz-Corrales, Francisco J.
Issue DateJul-2019
PublisherElsevier BV
CitationStem Cell Research 38: 101473 (2019)
AbstractAge-related macular degeneration (AMD) is the leading cause of adult blindness in developed countries and is characterized by progressive degeneration of the macula, the central region of the retina. A human induced pluripotent stem cell (hiPSC) line was derived from peripheral blood mononuclear cells (PBMCs) from a patient with a clinical diagnosis of dry AMD carrying the CFH Y402H polymorphism. Sendai virus was using for reprogramming and the pluripotent and differentiation capacity of the cells were assessed by immunocytochemistry and RT-PCR.
Publisher version (URL)http://dx.doi.org/10.1016/j.scr.2019.101473
Identifiersdoi: 10.1016/j.scr.2019.101473
e-issn: 1876-7753
issn: 1873-5061
Appears in Collections:(CABIMER) Artículos
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