Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/202412
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Regulation of mitotic exit by cell cycle checkpoints: Lessons from Saccharomyces cerevisiae |
Autor: | Matellán, Laura CSIC ORCID; Monje-Casas, Fernando CSIC ORCID | Palabras clave: | Mitosis Checkpoint DNA damage Chromosome segregation Aneuploidy |
Fecha de publicación: | 2020 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | Genes 11(2): 195 (2020) | Resumen: | In order to preserve genome integrity and their ploidy, cells must ensure that the duplicated genome has been faithfully replicated and evenly distributed before they complete their division by mitosis. To this end, cells have developed highly elaborated checkpoints that halt mitotic progression when problems in DNA integrity or chromosome segregation arise, providing them with time to fix these issues before advancing further into the cell cycle. Remarkably, exit from mitosis constitutes a key cell cycle transition that is targeted by the main mitotic checkpoints, despite these surveillance mechanisms being activated by specific intracellular signals and acting at different stages of cell division. Focusing primarily on research carried out using Saccharomyces cerevisiae as a model organism, the aim of this review is to provide a general overview of the molecular mechanisms by which the major cell cycle checkpoints control mitotic exit and to highlight the importance of the proper regulation of this process for the maintenance of genome stability during the distribution of the duplicated chromosomes between the dividing cells. | Descripción: | This article belongs to the Special Issue Chromosome Segregation Defects in the Origin of Genomic Instability. | Versión del editor: | https://doi.org/10.3390/genes11020195 | URI: | http://hdl.handle.net/10261/202412 | DOI: | 10.3390/genes11020195 | E-ISSN: | 2073-4425 |
Aparece en las colecciones: | (CABIMER) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Regulation_Matellan_Art2020.pdf | 541,99 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
13
checked on 19-abr-2024
SCOPUSTM
Citations
18
checked on 23-abr-2024
WEB OF SCIENCETM
Citations
17
checked on 25-feb-2024
Page view(s)
115
checked on 24-abr-2024
Download(s)
251
checked on 24-abr-2024