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Título: | Non-motor symptoms burden, mood, and gait problems are the most significant factors contributing to a poor quality of life in non-demented Parkinson's disease patients: Results from the COPPADIS Study Cohort |
Autor: | Santos-García, Diego; Deus Fonticoba, T. de; Suárez-Castro. Ester; Borrué, Carmen; Mata, M.; Solano Vila, Berta; Cots Foraster, Ana; Álvarez-Sauco, María; Rodríguez Pérez, A. B.; Vela-Desojo, Lydia; Macías, Y.; Fernández Guillán, N.; Grau Solá, M.; Gastón, Itziar; Kulisevsky, Jaime; Labandeira, C.; Gámez, Pedro; Gallego, M.; García Caldentey, Juan; García Campos, C.; González-Aramburu, Isabel; Labrador, Miguel Ángel CSIC ORCID; López-Díaz, Luis M.; López Seoane, B.; González Ardura, Jessica; González García, B.; González Palmás, M. J.; González Toledo, G. R.; Guardia, G.; Martí Andres, G.; Kurtis, Mónica; Méndez-Del Barrio, Carlota CSIC; Miranda Santiago, J.; Hernández-Vara, Jorge; Horta-Barba, Andrea; Infante, Jon; Jesús Maestre, Silvia CSIC ORCID; López-Manzanares, Lydia; Ordás, Carlos; Pareés, I.; Lacruz, F.; Lage Castro, M.; Legarda, Inés; López-Ariztegui, Nuria; Martí, María-José; Pascual-Sedano, Berta; Pol Fuster, J.; Prieto Jurczynska, C.; Martínez-Castrillo, J. C.; McAfee, Darrian; Meitín, M. T.; Menéndez-González, Manuel; Morales Casado, M. I.; Puente, Víctor; Pagonabarraga-Mora, Javier; Sánchez Alonso, Pilar; Sánchez-Carpintero, M.; Moreno Diéguez, A.; Nogueira, Víctor; Novo Amado, A.; Novo Ponte, S.; Prats, M. A.; Serarols, A.; Tartari, J. P.; Pastor, Pau; Pérez Fuertes, A.; Pérez Noguera, R.; Planellas, Lluís; Redondo Rafales, N.; Vargas-González, Laura CSIC ORCID; Escalante, Sonia; Reverté Villarroya, S.; Rodríguez Méndez, L.; Roldán, Florinda; Ruíz de Arcos, María; Ruiz Martínez, Javier; Sánchez Díez, G.; Cubo, Esther; Sierra Peña, M.; Martínez-Martín, Pablo; Almería, M.; Sánchez Rodríguez, Antonio; Santacruz, P.; Segundo Rodríguez, J. C.; Seijo-Martínez, Manuel; Esteve, P.; Aquilar, M.; Bernardo Lambrich, N.; Vázquez Gómez, R.; Villanueva, Clara; Vives, B.; Villar, M. D.; Casas, E.; Bejr-Kasem, Helena; Adarmes Gómez, A. D. CSIC ORCID; Cámara Lorenzo, A.; Arnaiz, S.; Carrillo, Fátima CSIC; Pueyo Morlans, Mercedes; Mir, Pablo CSIC ORCID; Alonso Losada, María G.; Carrillo, Fátima CSIC; Ávila-Rivera, María A.; Díez-Fairen, Mónica; Estelrich Peyret, E.; Alonso Cánovas, Araceli; Alonso-Frech, F.; Arribas, S.; Ascunde Vidondo, A.; Blázquez-Estrada, Marta; García-Moreno, José Manuel; Gómez-Garre, Pilar CSIC ORCID; Botí, M.; Cabello González, C.; Cabo-Lopez, Iria; Caballol, Nuria; Catalán, M. J.; González Aloy, J.; Erro, E.; Golpe Díaz, A.; Clavero, Pedro; Cortina Fernández, A.; Crespo Cuevas, A.; Fábregues-Boixar, Oriol de | Palabras clave: | Gait Mood Motor fluctuations Non-motor symptoms Parkinson's disease Quality of life |
Fecha de publicación: | sep-2019 | Editor: | Elsevier | Citación: | Parkinsonism and Related Disorders 60: 151-157 (2019) | Resumen: | [Objective] To identify factors related to a poor health-related and global quality of life (QoL) in a cohort of non-demented Parkinson's disease (PD) patients and compare to a control group. [Methods] The data correspond to the baseline evaluation of the COPPADIS-2015 Study, an observational, 5-year follow-up, multicenter, evaluation study. Three instruments were used to assess QoL: (1) the 39-item Parkinson's disease Questionnaire (PDQ-39), (2) a subjective rating of global QoL (PQ-10), and (3) the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Multiple linear regression methods were used to evaluate the direct impact of different variables on these QoL measures. [Results] QoL was worse in PD patients (n = 692; 62.6 ± 8.9 years old, 60.3% males) than controls (n = 206; 61 ± 8.3 years old, 49.5% males): PDQ-39, 17.1 ± 13.5 vs 4.4 ± 6.3 (p < 0.0001); PQ-10, 7.3 ± 1.6 vs 8.1 ± 1.2 (p < 0.0001); EUROHIS-QOL8, 3.8 ± 0.6 vs 4.2 ± 0.5 (p < 0.0001). A high correlation was observed between PDQ-39 and Non-Motor Symptoms Scale (NMSS) (r = 0.72; p < 0.0001), and PDQ-39 and Beck Depression Inventory-II (BDI-II) (r = 0.65; p < 0.0001). For health-related QoL (PDQ-39), non-motor symptoms burden (NMSS), mood (BDI-II), and gait problems (Freezing Of Gait Questionnaire [FOGQ]) provided the highest contribution to the model (β = 0.32, 0.28, and 0.27, respectively; p < 0.0001); whereas mood and gait problems contributed the most to global QoL (PQ-10, β = -0.46 and −0.21, respectively; EUROHIS-QOL8, β = -0.44 and −0.23, respectively). [Conclusions] QoL is worse in PD patients than in controls. Mood, non-motor symptoms burden, and gait problems seem to be the most relevant factors affecting health-related and global perceived QoL in non-demented PD patients. |
Versión del editor: | https://doi.org/10.1016/j.parkreldis.2019.07.031 | URI: | http://hdl.handle.net/10261/201919 | DOI: | 10.1016/j.parkreldis.2019.07.031 | ISSN: | 1353-8020 |
Aparece en las colecciones: | (IBIS) Artículos |
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