Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/201717
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Title

Bactericidal ZnO glass-flled thermoplastic polyurethane and polydimethyl siloxane composites to inhibit bioflm-associated infections

AuthorsCabal, Belén CSIC ORCID ; Sevillano, David; Fernández-García, Elisa CSIC; Alou, Luis; Suárez, Marta CSIC ORCID; González, Natalia; Moya, J. S. CSIC; Torrecillas, Ramón CSIC ORCID CVN
Issue Date2019
PublisherSpringer Nature
CitationScientific Reports 9: 2762 (2019)
AbstractThis study investigates a novel approach to controlling biofilms of the most frequent pathogens implicated in the etiology of biomaterials-associated infections. New bactericidal filler based on a non-toxic glass, belonging to B2O3-SiO2-Al2O3-Na2O-ZnO system, was used to formulate composites of the most widely used polymers in biomedical applications [i.e. thermoplastic polyurethane (TPU) and polydimethyl siloxane (PDMS)], with varying percentage by weight of the bactericidal glass (5, 15, 25, 35, 50%). Glass-filled polymer composites show dramatically restricted bacterial colonisation and biofilm formation. They exhibit time- and dose-dependent killing, with maximal action at 5 days. The highest activity was found against S.epidermidis biofilm (99% of reduction), one of the most common cause of nosocomial infections. The tensile properties of the obtained glass-filled composites are comparable with the literature data concerning polymeric biomaterials for medical implants and devices. In addition, all the materials presented in this research, revealed an excellent biocompatibility. This was disclosed by cell viability values above 70%, none alteration on erythrocyte membrane or cell functionality in contact with materials (haemolytic index 0–2%), and absence of interferences in blood coagulation (intrinsic, extrinsic and final pathways).
Publisher version (URL)https://doi.org/10.1038/s41598-019-39324-w
URIhttp://hdl.handle.net/10261/201717
DOI10.1038/s41598-019-39324-w
E-ISSN2045-2322
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