English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/201695
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorVarela, Mónicaes_ES
dc.contributor.authorForn-Cuni, Gabrieles_ES
dc.contributor.authorDios, S.es_ES
dc.contributor.authorFigueras Huerta, Antonioes_ES
dc.contributor.authorNovoa, Beatrizes_ES
dc.date.accessioned2020-02-24T11:33:51Z-
dc.date.available2020-02-24T11:33:51Z-
dc.date.issued2016-
dc.identifier.citationJournal of Innate Immunity 8: 43-56 (2016)es_ES
dc.identifier.issn1662-811X-
dc.identifier.urihttp://hdl.handle.net/10261/201695-
dc.description14 pages, 9 figureses_ES
dc.description.abstractIn mammals, perforins play a central role in the granule-dependent cell death induced by natural killer T cells and cytotoxic T lymphocytes, and participate both in the defense against virus-infected and neoplastic cells and in the recognition of nonself molecules by the immune system. Little is known about fish perforin genes. We examined the zebrafish with the aim of increasing our knowledge about the role of perforins. We characterized 6 perforin genes in the zebrafish genome, and we studied them at the evolutionary level in combination with expression patterns in several tissues and cell populations, during both larval development and in the course of a viral infection. Our results suggest the specialization of different cell types in the production of perforins. Moreover, functional diversification during the evolution of these molecules could be inferred from this study. In particular, one of the genes, prf19b , which is mainly produced by myeloid cells, seemed to be involved in antiviral defense, conferring protection after an in vivo infectiones_ES
dc.description.sponsorshipThis work was funded by the projects CSD2007–00002 ‘Aquagenomics’ and AGL2014–51773-C3 from the Spanish Ministerio de Economía y Competitividad. M. Varela received a predoctoral grant from the JAE Program (funded by the CSIC and European Social Funds).es_ES
dc.language.isoenges_ES
dc.publisherS. Karger AGes_ES
dc.relationMINECO/ICTI2013-2016/AGL2014-51773-C3-2-Res_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.subjectZebrafishes_ES
dc.subjectEvolutiones_ES
dc.subjectMPEG1es_ES
dc.subjectPerforinses_ES
dc.subjectInflammasomees_ES
dc.subjectViruses_ES
dc.titleProinflammatory Caspase A Activation and an Antiviral State Are Induced by a Zebrafish Perforin after Possible Cellular and Functional Diversification from a Myeloid Ancestores_ES
dc.typeartículoes_ES
dc.identifier.doi10.1159/000431287-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1159/000431287es_ES
dc.identifier.e-issn1662-8128-
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
Appears in Collections:(IIM) Artículos
Files in This Item:
File Description SizeFormat 
Proinflammatory_caspase_2016.pdf1,21 MBAdobe PDFThumbnail
View/Open
Show simple item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.