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A positional scanning combinatorial library of peptoids as a source of biological active molecules: identification of antimicrobials

AuthorsHumet, Marc; Carbonell, Teresa; Masip, Isabel ; Sánchez Baeza, Francisco J. ; Mora, Puig; Cantón, Emilia; Gobernado, Miguel; Abad, Concepción; Pérez-Payá, Enrique ; Messeguer Peypoch, Ángel
KeywordsPositional scanning library
Antimicrobial activity
Issue Date13-Jun-2003
PublisherAmerican Chemical Society
CitationJournal of Combinatorial Chemistry 5(5): 597-605 (2003)
AbstractA positional scanning library of N-alkylglycine trimers (peptoids) containing over 10 000 compounds has been synthesized on solid phase. The synthetic pathway involved the use of the submonomer strategy and a set of 22 commercially available primary amines as a chemical diversity source. The unbiased nature of the library allowed its screening against a variety of biological targets, leading to the identification of individual peptoids exhibiting remarkable biological activities (García-Martínez, C. et al. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 2374. Montoliu, et al. J. Pharm. Exp. Therap. 2002, 302, 29. Planells-Cases, R., et al. J. Pharm. Exp. Therap. 2002, 302, 163). In the present work, the screening of this library against a panel of Gram-positive and Gram-negative bacteria led to the identification of different compounds exhibiting antimicrobial activity.
Description9 pages, 4 figures, 2 schemes, 3 tables.-- PMID: 12959560 [PubMed].-- Printed version published in issue Sep-Oct 2003.-- Supporting information available at: http://pubs.acs.org/doi/suppl/10.1021/cc020075u
Publisher version (URL)http://dx.doi.org/10.1021/cc020075u
Appears in Collections:(IQAC) Artículos
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