Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/201412
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Campbell, Kyra | - |
dc.contributor.author | Rossi, Fabrizio | - |
dc.contributor.author | Adams, Jamie | - |
dc.contributor.author | Pitsidianaki, Ioanna | - |
dc.contributor.author | Barriga, Francisco M. | - |
dc.contributor.author | Garcia-Gerique, Laura | - |
dc.contributor.author | Batlle, Eduard | - |
dc.contributor.author | Casanova, Jordi | - |
dc.contributor.author | Casali, Andreu | - |
dc.date.accessioned | 2020-02-20T13:46:00Z | - |
dc.date.available | 2020-02-20T13:46:00Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Nature Communications 10: 2311 (2019) | - |
dc.identifier.uri | http://hdl.handle.net/10261/201412 | - |
dc.description | © The Author(s) 2019. | - |
dc.description.abstract | Metastasis underlies the majority of cancer-related deaths yet remains poorly understood due, in part, to the lack of models in vivo. Here we show that expression of the EMT master inducer Snail in primary adult Drosophila intestinal tumors leads to the dissemination of tumor cells and formation of macrometastases. Snail drives an EMT in tumor cells, which, although retaining some epithelial markers, subsequently break through the basal lamina of the midgut, undergo a collective migration and seed polyclonal metastases. While metastases re-epithelialize over time, we found that early metastases are remarkably mesenchymal, discarding the requirement for a mesenchymal-to-epithelial transition for early stages of metastatic growth. Our results demonstrate the formation of metastases in adult flies, and identify a key role for partial-EMTs in driving it. This model opens the door to investigate the basic mechanisms underlying metastasis, in a powerful in vivo system suited for rapid genetic and drug screens. | - |
dc.description.sponsorship | This study was supported by grants from the Ministerio de Economía y competitividad (Grant Numbers BFU2014–59781-P (to A.C.), BFU2015–73494-JIN (to K.C.), BFU2015–66488-P (to J.C.)). This work was also supported by the Joseph Steiner Foundation (to E.B.) and a Wellcome Trust/Royal Society Sir Henry Dale Award to K.C. (Grant number R/148777–11–1). | - |
dc.language | eng | - |
dc.publisher | Springer Nature | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2014–59781-P | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2015-73494-JIN | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2015-66488-P | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | Cancer | - |
dc.subject | Cancer models | - |
dc.subject | Cell biology | - |
dc.subject | Cell migration | - |
dc.subject | Metastasis | - |
dc.title | Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1038/s41467-019-10269-y | - |
dc.relation.publisherversion | http://dx.doi.org/10.1038/s41467-019-10269-y | - |
dc.identifier.e-issn | 2041-1723 | - |
dc.date.updated | 2020-02-20T13:46:00Z | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Wellcome Trust | - |
dc.contributor.funder | Royal Society (UK) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100004440 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000288 | es_ES |
dc.identifier.pmid | 31127094 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
Aparece en las colecciones: | (IBMB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Collective_Campbell_Art2019.pdf | 11,51 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
44
checked on 05-abr-2024
SCOPUSTM
Citations
68
checked on 15-abr-2024
WEB OF SCIENCETM
Citations
62
checked on 26-feb-2024
Page view(s)
191
checked on 19-abr-2024
Download(s)
157
checked on 19-abr-2024