English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/201412
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors

AuthorsCampbell, Kyra; Rossi, Fabrizio; Adams, Jamie; Pitsidianaki, Ioanna; Barriga, Francisco M.; Garcia-Gerique, Laura; Batlle, Eduard; Casanova, Jordi ; Casali, Andreu
Cancer models
Cell biology
Cell migration
Issue Date2019
PublisherSpringer Nature
CitationNature Communications 10: 2311 (2019)
AbstractMetastasis underlies the majority of cancer-related deaths yet remains poorly understood due, in part, to the lack of models in vivo. Here we show that expression of the EMT master inducer Snail in primary adult Drosophila intestinal tumors leads to the dissemination of tumor cells and formation of macrometastases. Snail drives an EMT in tumor cells, which, although retaining some epithelial markers, subsequently break through the basal lamina of the midgut, undergo a collective migration and seed polyclonal metastases. While metastases re-epithelialize over time, we found that early metastases are remarkably mesenchymal, discarding the requirement for a mesenchymal-to-epithelial transition for early stages of metastatic growth. Our results demonstrate the formation of metastases in adult flies, and identify a key role for partial-EMTs in driving it. This model opens the door to investigate the basic mechanisms underlying metastasis, in a powerful in vivo system suited for rapid genetic and drug screens.
Description© The Author(s) 2019.
Publisher version (URL)http://dx.doi.org/10.1038/s41467-019-10269-y
Appears in Collections:(IBMB) Artículos
Files in This Item:
File Description SizeFormat 
Collective_Campbell_Art2019.pdf11,51 MBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.