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Título

Role of A-type lamins in signaling, transcription and chromatin organization

AutorAndrés, Vicente; González, José María
Palabras claveNuclear envelope
Lamin-A/C
gene transcription
cell signaling
chromatin
laminopathies
Fecha de publicación28-dic-2009
EditorRockefeller University Press
CitaciónJournal of Cell Biology 187(7): 945-57 (2009)
ResumenA-type lamins (lamin-A and -C), encoded by the LMNA gene, are major protein constituents of the mammalian nuclear lamina, a complex structure that acts as a scaffold for protein complexes that regulate nuclear structure and functions. Interest in these proteins has increased in recent years with the discovery that LMNA mutations cause a variety of human diseases termed laminopathies, including progeroid syndromes and disorders that primarily affect striated muscle, adipose, bone and neuronal tissues. In this review we discuss recent research supporting the concept that lamin-A/C and associated nuclear envelope proteins regulate gene expression in health and disease through interplay with signal transduction pathways, transcription factors and chromatin-associated proteins.
Descripción13 pages, 4 figures. -- PMID: 20038676 [PubMed]
Versión del editorhttp://dx.doi.org/10.1083/jcb.200904124
URIhttp://hdl.handle.net/10261/20096
DOI10.1083/jcb.200904124
ISSN0021-9525
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