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Título: | Polyphenolic Extract (PE) from Olive Oil Exerts a Potent Immunomodulatory Effect and Prevents Graft-versus-Host Disease in a Mouse Model |
Autor: | Álvarez-Laderas, Isabel; Lopes Ramos, Teresa CSIC ORCID; Medrano, Mayte; Caracuel-García, Rocío CSIC; Barbado, Victoria; Sánchez-Hidalgo, Marina CSIC ORCID; Zamora, Rosario CSIC ORCID ; Alarcón de la Lastra, Catalina; Hidalgo, Francisco J. CSIC ORCID ; Piruat, José I. CSIC; Caballero-Velázquez, Teresa CSIC ORCID; Pérez-Simón, José A. CSIC ORCID | Palabras clave: | Graft-versus-host disease Mouse models Virgin olive oil Polyphenolic extract |
Fecha de publicación: | abr-2020 | Editor: | Elsevier | Citación: | Biology of Blood and Marrow Transplantation 26(4): 615-624 (2020) | Resumen: | Polyphenols are a group of chemical substances found in plants, with immunomodulatory, antiproliferative, and anti-inflammatory properties that might be useful in the prophylaxis and treatment of graft-versus-host disease (GVHD). Polyphenolic extract (PE) obtained from extra virgin olive oil (EVOO) decreased the activation and proliferation of activated T cells. In addition, a decreased production of proinflammatory cytokines was observed upon exposure to PE. Western blot assays showed a marked inhibition of Akt phosphorylation and nuclear translocation of NF-κB in activated T cells. In a murine model of acute GVHD, we observed that mice that received a diet supplemented in PE (600 ppm) presented a higher survival rate and lower risk of developing GVHD when compared with the group that received a control diet. Histopathologic examination showed a significantly lower gut involvement in mice receiving PE, with a decrease in proinflammatory cytokines (IL-2, IL-17, and TNF-α) in serum and the reestablishment of butyrate concentration in the gut. In conclusion, PE obtained from EVOO exerted a potent immunomodulatory effect, reducing the activation and proliferation of activated T cells and the production of proinflammatory cytokines. In a murine model of acute GVHD, a PE-supplemented diet reduced the incidence and severity of the disease and increased survival after transplantation. | Descripción: | 9 Figuras | Versión del editor: | http://dx.doi.org/10.1016/j.bbmt.2019.11.019 | URI: | http://hdl.handle.net/10261/200939 | ISSN: | 1083-8791 | E-ISSN: | 1523-6536 |
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