English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/200282
Share/Impact:
Statistics
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Fully Water-Soluble Polyphosphorhydrazone-Based Radical Dendrimers Functionalized with Tyr-PROXYL Radicals as Metal-Free MRI T1 Contrast Agents

AuthorsPinto, Luiz Fernando; Lloveras, Vega ; Zhang, Songbai; Liko, Flonja; Veciana, Jaume ; Muñoz Gómez, José L ; Vidal Gancedo, José
KeywordsRadical dendrimers
Magnetic resonance imaging MRI
Contrast agents
Electron paramagnetic resonance EPR
Organic radicals
Issue Date21-Jan-2020
PublisherAmerican Chemical Society
CitationACS Applied Bio Materials 3(1): 369-376 (2020)
AbstractThe finding of alternative imaging probes to Gadolinium (Gd) and other metal based contrast agents (CA) is crucial to overcome their established toxicity. Herein we describe the synthesis and characterization of an entirely organic metal-free magnetic resonance imaging (MRI) contrast agent based on polyphosphorhydrazone (PPH) dendrimers, fully functionalized with up to 48 organic nitroxide radical units. We propose an innovative synthetic procedure based on the use of an amino acid linker (Tyr) coupled to each dendrimer′s branch that permits the anchoring of the radicals and at the same time makes possible the control over their water solubility. We demonstrate that the negatively charged resulting PPH GnTyr-PROXYL (n = 0−3) radical dendrimers are excellent candidates to be used as MRI contrast agents, suited for biomedical applications as they show high water solubility, no aggregation problems, and low cytotoxicity, as well as good stability in highly reducing environments. It is achieved a remarkable r1 relaxivity, ca. four times higher (13 mM−1 s −1 ) than the gold-standard Gd-DTPA used in clinics. Furthermore, the r1 and r2 relaxivity per unit of radical showed an increase with the increase in generation of dendrimers.
Publisher version (URL)http://dx.doi.org/10.1021/acsabm.9b00855
URIhttp://hdl.handle.net/10261/200282
E-ISSN2576-6422
Appears in Collections:(ICMAB) Artículos
Files in This Item:
File Description SizeFormat 
Pinto_ACSApplBiom_2020_postprint.pdf Embargoed until January 21, 20211,03 MBAdobe PDFThumbnail
View/Open    Request a copy
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.