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Cationic Niosomes within Supramolecular Hydrogels as Novel Drug Delivery Systems for Oligonucleotides

AuthorsGrijalvo, Santiago CSIC ORCID; Puras, Gustavo; Zárate, Jon; Pons Pons, Ramon; Pedraz, José Luis, Eritja Casadellà, Ramón; Díaz Díaz, David CSIC ORCID
Issue Date30-Nov-2015
AbstractLow molecular weight supramolecular hydrogels (LMW) based on N-terminally-Fmoc-protected phenylalanine (Fmoc-Phe-OH) were used to encapsulate cationic niosomes containing an oligonucleotide covalently modified with fluorescein (FITC-ODN). Moreover, these LMW hydrogels were successfully tuned by adding ¿-carrageenan biopolymer. Interestingly, LMW containing both cationic niosomes and biopolymer did not affect the gelation properties of the supramolecular hydrogel. In vitro release experiments from Fmoc-Phe-OH hydrogels containing cationic niosomes were studied. The oligonucleotide release profile was modulated by tuning the supramolecular hydrogel with ¿-carrageenan and the release was governed by diffusion mechanisms. These results may indicate the suitability of these hybrid systems as drug delivery vehicles for oligonucleotides.
Appears in Collections:(IQAC) Comunicaciones congresos
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