English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/200044
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Intrapopulation variability in mutator prevalence among urinary tract infection isolates of Escherichia coli

AuthorsCouce, Alejandro; Alonso-Rodríguez, N.; Costas, Coloma; Oliver, Antonio; Blázquez Gómez, Jesús
KeywordsAntibiotic resistance
Hypermutability
Mutator
mutL
mutY
Issue DateJun-2016
PublisherElsevier
CitationClinical Microbiology and Infection 22(6): 566.e1-566.e7 (2016)
AbstractBacteria with elevated mutation rates represent a risk factor for treatment failure and are often found with high frequency in clinical isolates from different sources. How this frequency reflects the among-population and within-population proportion of hypermutators is unknown, despite its importance to the choice of antibiotic therapies that minimize the likelihood of resistance development. Here we screened for hypermutators among the urine of 80 patients with urinary tract infections, at an unprecedented resolution of 24 isolates per sample. We found hypermutators in four patients (5%), at frequencies ranging from 4.2% to 62.5%. Molecular characterization revealed alterations in the oxidized guanine (GO) and methly-directed mistmatch repair (MMR) systems as the genetic basis of hypermutability. These observations suggest that mutators may be present in more patients than previously anticipated, at frequencies that are difficult to detect but still sufficient to impact on adaptation to antibiotics or the host environment.
Publisher version (URL)http://dx.doi.org/10.1016/j.cmi.2016.03.008
URIhttp://hdl.handle.net/10261/200044
DOI10.1016/j.cmi.2016.03.008
Identifiersdoi: 10.1016/j.cmi.2016.03.008
e-issn: 1469-0691
issn: 1198-743X
Appears in Collections:(CNB) Artículos
(IBIS) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.