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Título: | A low-cost integrated biosensing platform based on SiN nanophotonics for biomarker detection in urine |
Autor: | Martens, Daan; Ramirez-Priego, Patricia CSIC ORCID; Murib, M. S.; Elamin, Ayssar A.; González-Guerrero, Ana Belén CSIC ORCID; Stehr, M.; Jonas, F.; Anton, Birgit; Hlawatsch, N.; Soetaert, Pieterjan; Vos, Rita; Stassen, A.; Severi, S.; Van Roy, Wim; Bockstaele, Ronny; Becker, Holger; Singh, Mahavir; Lechuga, Laura M. CSIC ORCID ; Bienstman, Peter | Fecha de publicación: | 2018 | Editor: | Royal Society of Chemistry (UK) | Citación: | Analytical Methods 10(25): 3066-3073 (2018) | Resumen: | We present a low-cost integrated nanophotonic lab-on-a-chip platform suitable for point-of-care (POC) biomarker analysis. The sensor chip included in the platform contains multiplexed Mach–Zehnder interferometers with an on-chip optical spectral analyser consisting of an arrayed-waveguide grating. The sensor chip is fabricated in silicon nitride material, which makes it compatible with consumer-electronics-grade sources and detectors, leading to the possibility of low-cost instrumentation. The nanophotonic sensor chip exhibits a detection limit of 6 × 10−6 RIU (Refractive Index Units), which is in the same order of magnitude as the reported values for state-of-the-art evanescent wave sensors. The sensor chip is biofunctionalised with specific bioreceptors and integrated into a polymer microfluidic cartridge. The POC instrumentation platform contains optical excitation and read-out sub-systems and dedicated on-board software for real-time analysis of patient samples. To demonstrate the versatility of the platform, we present results both on the detection of an antigen related to tuberculosis directly in urine samples using a laboratory prototype and on the detection of a protein biomarker (CRP) related to inflammation using the integrated instrument. | Versión del editor: | https://doi.org/10.1039/C8AY00666K | URI: | http://hdl.handle.net/10261/199029 | DOI: | 10.1039/C8AY00666K | ISSN: | 1759-9660 | E-ISSN: | 1759-9679 |
Aparece en las colecciones: | (CIN2) Artículos |
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