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Title

Haploid selection within a single ejaculate increases offspring fitness

AuthorsAlavioon, Ghazal; Hotzy, Cosima; Nakhro, Khriezhanuo; Rudolf, Sandra; Scofield, Douglas G.; Zajitschek, Susanne; Maklakov, Alexei A.; Immler, Simone
Keywordsbiphasic life cycle
sperm selection
sperm genotype
sexual reproduction
gametic selection
Issue DateJun-2017
PublisherNational Academy of Sciences (U.S.)
CitationProceedings of the National Academy of Sciences of the United States of America 114(30): 8053-8058 (2017)
AbstractAn inescapable consequence of sex in eukaryotes is the evolution of a biphasic life cycle with alternating diploid and haploid phases. The occurrence of selection during the haploid phase can have far-reaching consequences for fundamental evolutionary processes including the rate of adaptation, the extent of inbreeding depression, and the load of deleterious mutations, as well as for applied research into fertilization technology. Although haploid selection is well established in plants, current dogma assumes that in animals, intact fertile sperm within a single ejaculate are equivalent at siring viable offspring. Using the zebrafish Danio rerio, we show that selection on phenotypic variation among intact fertile sperm within an ejaculate affects offspring fitness. Longer-lived sperm sired embryos with increased survival and a reduced number of apoptotic cells, and adult male offspring exhibited higher fitness. The effect on embryo viability was carried over into the second generation without further selection and was equally strong in both sexes. Sperm pools selected by motile phenotypes differed genetically at numerous sites throughout the genome. Our findings clearly link within-ejaculate variation in sperm phenotype to offspring fitness and sperm genotype in a vertebrate and have major implications for adaptive evolution.
Publisher version (URL)http://doi.org/10.1073/pnas.1705601114
URIhttp://hdl.handle.net/10261/199000
DOI10.1073/pnas.1705601114
Identifiersdoi: 10.1073/pnas.1705601114
issn: 1091-6490
e-issn: 0027-8424
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