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dc.contributor.authorCampos, Brunoes_ES
dc.contributor.authorRivetti, Claudiaes_ES
dc.contributor.authorTauler, Romàes_ES
dc.contributor.authorPiña, Benjamínes_ES
dc.contributor.authorBarata Martí, Carloses_ES
dc.date.accessioned2020-01-27T09:08:05Z-
dc.date.available2020-01-27T09:08:05Z-
dc.date.issued2019-12-01-
dc.identifier.citationScientific Reports 9 (1): 3693 (2019)es_ES
dc.identifier.urihttp://hdl.handle.net/10261/198926-
dc.description.abstractSerotonin has a pivotal function regulating development, growth, reproduction and behavior in animals. In this paper, we studied the deregulatory effects of the deprivation of serotonin in Daphnia magna TRH CRISPR-Cas9 mutants. Bi-allelic in-del THR mutants and, to a lesser extent, mono-allelic ones grew less, reproduced later, and produced smaller clutches than wild type clones. Transcriptomic and functional gene analyses showed a down-regulation of growth/molting and energy metabolism signaling pathways in TRH mutants, while revealing marked differences between mono- and bi-allelic clones. Bi-allelic mutants, lacking serotonin, presented the serotonergic synapse and arachidonic acid metabolic pathways down-regulated while the tryptophan to kynurenine was upregulated, thus indicating a cross-talk between the serotonergic and arachidonic acid metabolic pathways. Finally, the effects on the insulin growth factor-mediated signaling pathway were marginal. These changes in functional and metabolic pathways are consistent with previously reported effects in D. magna exposed to pharmaceuticals that inhibited arachidonic metabolism or enhanced the levels of serotonin. © 2019, The Author(s).es_ES
dc.description.sponsorshipThis work was supported by European Research Council under the European Union’s Seventh Framework Programme (FP/2007–2013)/ERC Grant Agreement No. 320737 and the Spanish Government projects (CTM2014-51985-R, CTM2017-83242-R).es_ES
dc.language.isoenges_ES
dc.publisherSpringer Naturees_ES
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/320737es_ES
dc.relationMINECO/ICTI2013-2016/CTM2014-51985-Res_ES
dc.relationMINECO/ICTI2017-2020/CTM2017-83242-Res_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.subjectMoltinges_ES
dc.subjectShrimpes_ES
dc.subjectHyperglycemic hormonees_ES
dc.titleTryptophan hydroxylase (TRH) loss of function mutations in Daphnia deregulated growth, energetic, serotoninergic and arachidonic acid metabolic signalling pathwayses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1038/s41598-019-39987-5-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1038/s41598-019-39987-5es_ES
dc.contributor.funderEuropean Research Counciles_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000781es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000781es_ES
dc.contributor.orcidCampos, Bruno [0000-0002-3701-4858]es_ES
dc.contributor.orcidRivetti, Claudia [0000-0002-8801-0718]es_ES
dc.contributor.orcidTauler, Romà [0000-0001-8559-9670]es_ES
dc.contributor.orcidPiña, Benjamín [0000-0001-9216-2768]es_ES
dc.contributor.orcidBarata Martí, Carlos [0000-0002-3360-0729]es_ES
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