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Title

Dietary oleic and palmitic acids modulate the ratio of triacylglycerols to cholesterol in postprandial triacylglycerol-rich lipoproteins in men and cell viability and cycling in human monocytes

AuthorsLópez, Sergio; Bermúdez, Beatriz CSIC ORCID; Pacheco, Yolanda M. CSIC ORCID; López-Lluch, Guillermo CSIC ORCID CVN ; Moreda, Wenceslao CSIC ORCID ; Villar, José; Abia, Rocío CSIC ORCID ; Muriana, Francisco J. G. CSIC ORCID
Issue Date2007
PublisherAmerican Society for Nutritional Sciences
Oxford University Press
CitationJournal of Nutrition 137(9): 1999-2005 (2007)
AbstractThe postprandial metabolism of dietary fats produces triacylglycerol (TG)-rich lipoproteins (TRL) that could interact with circulating cells. We investigated whether the ratios of oleic:palmitic acid and monounsaturated fatty acids (MUFA):SFA in the diet affect the ratio of TG:cholesterol (CHOL) in postprandial TRL of healthy men. The ability of postprandial TRL at 3 h (early postprandial period) and 5 h (late postprandial period) to affect cell viability and cycle in the THP-1 human monocytic cell line was also determined. In a randomized, crossover experiment, 14 healthy volunteers (Caucasian men) ate meals enriched (50 g/m2 body surface area) in refined olive oil, high-palmitic sunflower oil, butter, and a mixture of vegetable and fish oils, which had ratios of oleic:palmitic acid (MUFA:SFA) of 6.83 (5.43), 2.36 (2.42), 0.82 (0.48), and 13.81 (7.08), respectively. The ratio of TG:CHOL in postprandial TRL was inversely correlated (r = 20.89 to 20.99) with the ratio of oleic:palmitic acid and with the MUFA:SFA ratio in the dietary fats (P < 0.05). Postprandial TRL at 3 h preferentially increased the proportion of necrotic cells, whereas postprandial TRL at 5 h increased the proportion of apoptotic cells (P < 0.05). Cell cycle analysis showed that postprandial TRL blocked the human monocytes in S-phase. Our findings suggest that the level of TG and CHOL into postprandial TRL is associated with the ratios of oleic:palmitic acid and MUFA:SFA in dietary fats, which determines the ability of postprandial TRL to induce cytotoxicity and disturb the cell cycle in THP-1 cells.
Publisher version (URL)https://doi.org/10.1093/jn/137.9.1999
URIhttp://hdl.handle.net/10261/198791
DOI10.1093/jn/137.9.1999
Identifiersdoi: 10.1093/jn/137.9.1999
issn: 0022-3166
e-issn: 1541-6100
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