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Gut Microbiota and Probiotics in Modulation of Epithelium and Gut-Associated Lymphoid Tissue Function

AuthorsSanz Herranz, Yolanda ; Palma, Giada de
KeywordsGut microbiota
Mucosal immunity
Regulatory T cells
Issue DateDec-2009
PublisherTaylor & Francis
CitationInternational Reviews of Immunology 28 (6): 397-413 (2009)
AbstractThe intestinal tract mucosa is exposed to a vast number of environmental antigens and a large community of commensal bacteria. The mucosal immune system has to provide both protection against pathogens and tolerance to harmless bacteria. Immune homeostasis depends on the interaction of indigenous commensal and transient bacteria (probiotics) with various components of the epithelium and the gut-associated lymphoid tissue. Herein, an update is given of the mechanisms by which the gut microbiota and probiotics are translocated through the epithelium, sensed via pattern-recognition receptors, and activate innate and adaptive immune responses.
Description17 pages, 2 figures.
Publisher version (URL)http://dx.doi.org/10.3109/08830180903215613
Appears in Collections:(IATA) Artículos
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