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dc.contributor.authorJiménez-Panizo, Albaes_ES
dc.contributor.authorPérez, Palomaes_ES
dc.contributor.authorRojas, A. M.es_ES
dc.contributor.authorFuentes-Prior, Pabloes_ES
dc.contributor.authorEstébanez-Perpiñá, Evaes_ES
dc.identifier.citationEndocrine Related Cancer 26(8):R479-R497 (2019)es_ES
dc.description18 páginas, 5 figuras, 1 tablaes_ES
dc.description.abstractNuclear receptors are transcription factors that play critical roles in development, homeostasis and metabolism in all multicellular organisms. An important family of nuclear receptors comprises those members that respond to steroid hormones, and which is subdivided in turn into estrogen receptor (ER) isoforms α and β (NR3A1 and A2, respectively), and a second subfamily of so-called oxosteroid receptors. The latter includes the androgen receptor (AR/NR3C4), the glucocorticoid receptor (GR/NR3C1), the mineralocorticoid receptor (MR/NR3C2) and the progesterone receptor (PR/NR3C3). Here we review recent advances in our understanding of the structure-and-function relationship of steroid nuclear receptors and discuss their implications for the etiology of human diseases. We focus in particular on the role played by AR dysregulation in both prostate cancer (PCa) and androgen insensitivity syndromes (AIS), but also discuss conditions linked to mutations of the GR gene as well as those in a non-steroidal receptor, the thyroid hormone receptor (TR). Finally, we explore how these recent results might be exploited for the development of novel and selective therapeutic strategies.es_ES
dc.description.sponsorshipE E P expresses her deepest gratitude to the generous and continuous private donations from Gemma E Carretero. E E P, P F P and P P acknowledge the RED Nacional de Receptores Nucleares (NurCaMeIn: SAF2017-71878-REDT and SAF2015-71878-REDT). E E P acknowledges the BFU-Retos2017-86906-R, P F P the SAF2014-57994-R, P P the SAF2017-88046-R and A R the RTI2018-096735-B-100 grants from the MINECO. E E P and P F P are thankful for the CaixaImpulse2017 (ARDIs) from La Caixa (Fundación Bancaria Caja de Ahorros y Pensiones de Barcelona, Obra Social La Caixa y Caixa Risc) and SGR2017 and LLAVOR2018 grants from the Generalitat de Catalunya. E E P acknowledges the F2I-FVAL and F2I-MiR grants from the EU FEDER and the Fundació Bosch i Gimpera (FBG).es_ES
dc.relationMINECO/ICTI2013-2016/ BFU-Retos2017-86906-Res_ES
dc.subjectAndrogen insensitivity syndromes (AIS)es_ES
dc.subjectAndrogen receptores_ES
dc.subjectGlucocorticoid receptores_ES
dc.subjectHormone resistancees_ES
dc.subjectLigand-binding domaines_ES
dc.subjectProstate canceres_ES
dc.subjectProtein structurees_ES
dc.titleNon-canonical dimerization of the androgen receptor and other nuclear receptors: implications for human diseasees_ES
dc.description.peerreviewedPeer reviewedes_ES
dc.contributor.funderRed Nacional de Receptores Nucleares (España)es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderObra Social la Caixaes_ES
dc.contributor.funderGeneralitat de Catalunyaes_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderFundación Bosch i Gimperaes_ES
oprm.item.hasRevisionno ko 0 false*
dc.contributor.orcidPérez, Paloma [0000-0002-7166-2824]es_ES
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