Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/198417
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dc.contributor.authorDaga, Rafael R.es_ES
dc.contributor.authorJiménez-Martínez, Juanes_ES
dc.date.accessioned2020-01-21T08:56:07Z-
dc.date.available2020-01-21T08:56:07Z-
dc.date.issued1999-
dc.identifier.citationJournal of Cell Science 112(18): 3137-3146 (1999)es_ES
dc.identifier.issn0021-9533-
dc.identifier.urihttp://hdl.handle.net/10261/198417-
dc.description.abstractThe eukaryotic translation initiation factor 4A (eIF4A) is an RNA helicase required for translation initiation of eukaryotic mRNAs. By engineering fission yeast mutants with diminished eIF4A activity, we have found that translation of cdc25 mRNAs (a dosage-dependent activator of mitosis in all eukaryotic cells) is particularly sensitive to limitations of protein synthesis mediated by limited eIF4A activity. Genetic and biochemical analysis indicated that a rate-limited translation initiation of cdc25 mRNAs, exerted throughout its unusual 5′ untranslated leader, acts as a molecular sensor to ensure that a minimum cell mass (protein synthesis) is attained before mitosis occurs. The Cdc13 cyclin B is also among the limited pool of proteins whose translation is sensitive to reduced translation initiation activity. Interestingly, the 5′ leader sequences of cdc25 and cdc13 mRNAs have conserved features which are unusual in other yeast mRNAs, suggesting that common mechanisms operate in the expression of these two key mitotic activators at the translational level.es_ES
dc.description.sponsorshipThis work was supported by the Spanish MEC and the Junta de Andalucía.es_ES
dc.language.isoenges_ES
dc.publisherCompany of Biologistses_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.subjectSize controles_ES
dc.subjectMitosises_ES
dc.subjectSchizosaccharomyces pombees_ES
dc.titleTranslational control of the cdc25 cell cycle phosphatase: a molecular mechanism coupling mitosis to cell growthes_ES
dc.typeartículoes_ES
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://jcs.biologists.org/content/112/18/3137.longes_ES
dc.identifier.e-issn1477-9137-
dc.contributor.funderJunta de Andalucíaes_ES
dc.contributor.funderMinisterio de Educación y Ciencia (España)es_ES
dc.relation.csicNoes_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011011es_ES
dc.identifier.pmid10462529-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairetypeartículo-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
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