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Título: | Effects of ethanol and dexamethasone on epidermis examined by in vitro 31P magnetic resonance spectroscopy |
Autor: | Sardón, S.; Sánchez-Alcázar, José Antonio CSIC ORCID ; Collier, S. W.; Loä Pez-Lacomba, J. L.; Cortijo, M.; Ruiz-Cabello, Jesús | Fecha de publicación: | 1998 | Editor: | Elsevier | Citación: | Journal of Pharmaceutical Sciences 87(2): 249-255 (1998) | Resumen: | We recently reported on the pharmacodynamic effects of a glucocorticoid on perfused, intact, viable epidermis assessed by intracellular phosphorus metabolism with 31PNMR spectroscopy. We also have recently determined that perfusion with different transdermal-penetration-enhancing agents, such as ethanol, DMSO, and propyleneglycol, results in similar effects, which could be related with those previously observed. In the first studies, dexa-methasone was solved in low concentrations of ethanol before addition to the perfusion media (final concentration 0.1%, v/v). In the present experiments, we tested our original protocol to possibly distinguish these effects. | Versión del editor: | https://doi.org/10.1021/js9701519 | URI: | http://hdl.handle.net/10261/198360 | DOI: | 10.1021/js9701519 | ISSN: | 0022-3549 | E-ISSN: | 1520-6017 |
Aparece en las colecciones: | (CAB) Artículos |
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