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http://hdl.handle.net/10261/197531
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Martínez, Rubén | es_ES |
dc.contributor.author | Navarro-Martín, Laia | es_ES |
dc.contributor.author | van Antro, Morgane | es_ES |
dc.contributor.author | Fuertes, Inmaculada | es_ES |
dc.contributor.author | Casado, Marta | es_ES |
dc.contributor.author | Barata Martí, Carlos | es_ES |
dc.contributor.author | Piña, Benjamín | es_ES |
dc.date.accessioned | 2020-01-09T08:02:30Z | - |
dc.date.available | 2020-01-09T08:02:30Z | - |
dc.date.issued | 2020-05-20 | - |
dc.identifier.citation | Chemosphere 246: 125704 (2020) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/197531 | - |
dc.description.abstract | Bisphenol A (BPA; 4,4’-(propane-2,2-diyl)diphenol) has been shown to act as an obesogen and to disrupt lipid metabolism in zebrafish eleutheroembryos (ZE). To characterize the consequences of this disruption, we performed a detailed lipidomic study using ZE exposed to different BPA concentrations (0, 4, 6 and 8 mg/L of BPA) from day 2 to up to day 6 post fertilization (dpf). Total lipids at 4, 5 and 6 dpf were extracted by Folch method and analyzed by high-performance thin layer chromatography (HPTLC) as wide-range preliminary screening. Selected conditions (0 and 6 mg/L of BPA) were used to obtain a high-quality lipid profile using ultra high-performance liquid chromatography/time-of-flight mass spectrometry (UHPLC-TOFMS). BPA exposed ZE exhibited increased amounts of triglycerides (TG), diglycerides (DG), phosphatidylcholines (PC) and phosphatidylinositols (PI), regarding the control group. Analysis of time- and BPA exposure-related patterns of specific lipid species showed a clear influence of unsaturation degree (mostly in DG and PC) and/or fatty acid chain length (mostly in TG and PC derivatives) on their response to the presence of BPA. A decreased yolk-sac and energy consumption in exposed individuals appeared as the main reason for the observed BPA-driven effects. Integration of these results with previous morphological, biochemical, transcriptomic, metabolomic and behavioral data suggests a disruption of different signalling pathways by BPA that starts at very low BPAconcentrations, whose effects propagate across different organization levels, and that cannot be only explained by the relatively weak estrogenic effect of BPA. © 2019 Elsevier Ltd | es_ES |
dc.description.sponsorship | This work was supported by grants from the Spanish Ministry of Economy and Competitiveness (CTQ2014-56777-R) and the Spanish Ministry of Science, Innovation and University (RTI2018-096175-B-I00). RM was supported by a FPU predoctoral fellow from the Spanish Ministry of Education, Culture and Sport (ref. FPU15/03332). IF was supported by a FPI predoctoral fellow from the Spanish Ministry of Economy and Competitiveness (FPI-MICINN BES-2015-075023). We thank Juan Carlos Navarro and Josefina Casas for his valuable advice and expertise in the optimization of the thin-layer chromatography technique and liquid chromatography/mass spectrometry, respectively. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2014-56777-R | es_ES |
dc.relation.ispartof | http://hdl.handle.net/10261/192701 | es_ES |
dc.relation.isversionof | Postprint | es_ES |
dc.rights | openAccess | en_EN |
dc.subject | Mass spectrometry | es_ES |
dc.subject | Adverse outcome pathway | es_ES |
dc.subject | Endocrine disruption | es_ES |
dc.subject | Phenols | es_ES |
dc.subject | Thin layer chromatography | es_ES |
dc.subject | Mode of action | es_ES |
dc.subject | Yolk sac malabsorption | es_ES |
dc.title | Changes in lipid profiles induced by bisphenol A (BPA) in zebrafish eleutheroembryos during the yolk sac absorption stage | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.chemosphere.2019.125704 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.chemosphere.2019.125704 | es_ES |
dc.embargo.terms | 2022-05-20 | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.contributor.orcid | Martínez, Rubén [0000-0001-9965-7042] | es_ES |
dc.contributor.orcid | Navarro-Martín, Laia [0000-0001-6554-8833] | es_ES |
dc.contributor.orcid | Fuertes, Inmaculada [0000-0001-8415-7993] | es_ES |
dc.contributor.orcid | Barata Martí, Carlos [0000-0002-3360-0729] | es_ES |
dc.contributor.orcid | PIÑA CAPO, BENJAMIN CAYETANO [0000-0001-9216-2768] | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
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Changes in lipid profiles induced by bisphenol A (BPA) in zebrafish eleutheroembryos during the yolk sac absorption stage.pdf | Artículo principal | 3,01 MB | Adobe PDF | Visualizar/Abrir |
1-s2.0-S0045653519329455-mmc1.xlsx | Material suplementario | 120,64 kB | Microsoft Excel XML | Visualizar/Abrir |
1-s2.0-S0045653519329455-mmc2.docx | Material suplementario | 627,84 kB | Microsoft Word XML | Visualizar/Abrir |
1-s2.0-S0045653519329455-mmc3.pdf | Material suplementario | 1,39 MB | Adobe PDF | Visualizar/Abrir |
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