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http://hdl.handle.net/10261/197362
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Straniero, Valentina | es_ES |
dc.contributor.author | Sebastián-Pérez, Víctor | es_ES |
dc.contributor.author | Hrast, Martina | es_ES |
dc.contributor.author | Zanotto, Carlo | es_ES |
dc.contributor.author | Casiraghi, Andrea | es_ES |
dc.contributor.author | Suigo, Lorenzo | es_ES |
dc.contributor.author | Zdovc, Irena | es_ES |
dc.contributor.author | Radaelli, Antonia | es_ES |
dc.contributor.author | de Giuli-Morghen, Carlo | es_ES |
dc.contributor.author | Valoti, Ermanno | - |
dc.date.accessioned | 2020-01-02T12:04:47Z | - |
dc.date.available | 2020-01-02T12:04:47Z | - |
dc.date.issued | 2019-11-21 | - |
dc.identifier.citation | ChemMedChem (2019) | es_ES |
dc.identifier.issn | 1860-7179 | - |
dc.identifier.uri | http://hdl.handle.net/10261/197362 | - |
dc.description | 16 p.-7 fig.-4 tab. | es_ES |
dc.description.abstract | FtsZ is a crucial prokaryotic protein involved in bacterial cell replication. It recently arose as a promising target in the search for antimicrobial agents able to fight antimicrobial resistance. In this work, going on with our structure-activity relationship (SAR) study, we developed variously 7-substituted 1,4-benzodioxane compounds, linked to the 2,6-difluorobenzamide by a methylenoxy bridge. Compounds exhibit promising antibacterial activities not only against multidrug-resistant Staphylococcus aureus, but also on mutated Escherichia coli strains, thus enlarging their spectrum of action toward Gram-negative bacteria as well. Computational studies elucidated, through a validated FtsZ binding protocol, the structural features of new promising derivatives as FtsZ inhibitors. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | John Wiley & Sons | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | 1,4-benzodioxane-2,6-difluorobenzamide | es_ES |
dc.subject | FtsZ inhibition | es_ES |
dc.subject | Mutated E. coli | es_ES |
dc.subject | Cavity detection | es_ES |
dc.subject | Molecular modelling | es_ES |
dc.title | Benzodioxane-benzamides as antibacterial agents: computational and SAR studies to evaluate the influence of the 7-substitution in FtsZ interaction | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1002/cmdc.201900537 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1002/cmdc.201900537 | es_ES |
dc.identifier.e-issn | 1860-7187 | - |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.contributor.orcid | Straniero, Valentina [0000-0002-5089-0879] | es_ES |
dc.contributor.orcid | Sebastián-Pérez, Víctor [0000-0002-8248-4496] | es_ES |
dc.contributor.orcid | Hrast, Martina [0000-0003-0488-2445] | es_ES |
dc.contributor.orcid | Zanotto, Carlo [0000-0003-0222-6102] | es_ES |
dc.contributor.orcid | Casiraghi, Andrea [0000-0002-6256-5694] | es_ES |
dc.contributor.orcid | Suigo, Lorenzo [0000-0002-8958-1547] | es_ES |
dc.contributor.orcid | Zdovc, Irena [0000-0002-5419-2779] | es_ES |
dc.contributor.orcid | Radaelli, Antonia [0000-0002-5683-6216] | es_ES |
dc.contributor.orcid | de Giuli-Morghen, Carlo [0000-0002-4127-3596] | es_ES |
dc.contributor.orcid | Valoti, Ermanno [0000-0002-5608-3875] | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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