English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/197343
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Lack of the aryl hydrocarbon receptor accelerates aging in mice

AuthorsBravo-Ferrer, Isabel; Cuartero, María Isabel; Medina, Violeta; Ahedo-Quero, Dalia; Peña-Martínez, Carolina; Pérez-Ruíz, Alberto; Fernández-Valle, Encarnación; Hernández-Sánchez, Catalina ; Fernández-Salguero, Pedro M.; Lizasoain, Ignacio; Moro, María A.
KeywordsAhR
Inflammaging
Neuroinflammation
Issue Date1-Nov-2019
PublisherFederation of American Society of Experimental Biology
CitationFASEB J 33(11):12644-12654 (2019)
AbstractThe aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor, largely known for its role in xenobiotic metabolism and detoxification as well as its crucial role as a regulator of inflammation. Here, we have compared a cohort wild-type and AhR-null mice along aging to study the relationship between this receptor and age-associated inflammation, termed as "inflammaging," both at a systemic and the CNS level. Our results show that AhR deficiency is associated with a premature aged phenotype, characterized by early inflammaging, as shown by an increase in plasma cytokines levels. The absence of AhR also promotes the appearance of brain aging anatomic features, such as the loss of the white matter integrity. In addition, AhR-/- mice present an earlier spatial memory impairment and an enhanced astrogliosis in the hippocampus when compared with their age-matched AhR+/+ controls. Importantly, we have found that AhR protein levels decrease with age in this brain structure, strongly suggesting a link between AhR and aging.-Bravo-Ferrer, I., Cuartero, M. I., Medina, V., Ahedo-Quero, D., Peña-Martínez, C., Pérez-Ruíz, A., Fernández-Valle, M. E., Hernández-Sánchez, C., Fernández-Salguero, P. M., Lizasoain, I., Moro, M. A. Lack of the aryl hydrocarbon receptor accelerates aging in mice.
Description11p.-5 fig.-1 tab.
Publisher version (URL)https://doi.org/10.1096/fj.201901333R
URIhttp://hdl.handle.net/10261/197343
DOI10.1096/fj.201901333R
ISSN0892-6638
E-ISSN1530-6860
Appears in Collections:(CIB) Artículos
Files in This Item:
File Description SizeFormat 
restringido.pdfRestringido20,59 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.