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Dosimetry studies for radiation therapy with photons and radiobiology using low-energy protons

AuthorsBattaglia, M. C. CSIC
AdvisorEspino, J. M. CSIC ORCID; Gallardo, M. I.; Schardt, D.
Issue Date15-Sep-2017
PublisherUniversidad de Sevilla
CSIC-JA-USE - Centro Nacional de Aceleradores (CNA)
AbstractThis thesis work is based on the knowledge about the interaction of radiation with matter to develop new methods with the aim of applying them to the radiation therapy and radiobiology, specifically to dose measurements in radiation therapy, dose measurements with low energy proton beams and DNA damages caused by these protons on cancer cells. Thus, it presents two main parts: one regarding the presentation of a novel prototype based on silicon detector technology for treatment verification in radiotherapy, and the other, the instrumentation and the methodology for low energy proton beam characterization, dosimetry, with a special focus on the response of radiochromic films to protons, and finally the application on biological samples to study the DNA damage produced by protons. The first part of this work presents a novel system with improved performances with respect to a previous system which was filed for a patent in September 13th 2011 at the OEMP - “Oficina Espa˜nola de Patentes y Marcas”- Ministry of Industry, Tourism and Commerce, under reference number P201101009. This work was also published in specialized reviews and thesis works. The characterization of the response in terms of absorbed dose of this novel detector was presented Here, this study was repeated because of some modifications introduced in the electronics and in one of the detector’s cables, which was modified due to a breakdown. The application of this system for complex treatment verification providing a 2D dose map reconstruction in the axial plane is presented for the first time in this thesis work. The second part of the work presents the installation of instrumentation for dosimetry and radiobiology studies using proton beams produced by the 3 MV Tandem accelerator at Centro Nacional de Acceleradores, Sevilla. The original work within this part can be divided into three main points: i) the elaboration of a protocol which allows to obtain a beam profile with low current and an homogeneous profile over the whole sample surface; ii) dosimetry with low energy protons using ionization chambers and radiochromic films; iii) study of the dosimetry at the Bragg peak. Last, the application of these studies to the irradiation of cell cultures is presented and preliminary results of the DNA damage produced by protons are shown.
DescriptionTesis llevada a cabo para conseguir el grado de Doctor por la Universidad de Sevilla--2017-09-15
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Appears in Collections:(CNA) Tesis

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