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HoF3 and DyF3 nanoparticles as dual contrast agents for MRI and CT

AuthorsBecerro, Ana Isabel ; González-Mancebo, Daniel; Corral, Ariadna; Balcerzyk, Marcin ; García-Martín, María L.
Issue Date28-May-2019
CitationNanoSpain Conference (2019)
AbstractUse of contrast agents (CAs) is frequently necessary in MRI (Magnetic Resonance Imaging) to increase the contrast between normal and abnormal tissues. Clinically used MRI CAs are based on gadolinium chelates and superparamagnetic iron oxide nanoparticles (SPIONS). Recently, Gd-based inorganic nanoparticles, such as NaGdF4,1 appeared as an interesting alternative due to their excellent contrast enhancement, long circulation times and the possibility of target specificity, which leads to reduced dose and minimized damage to normal tissues. However, although Gd-based nanoparticles provide good contrast characteristics at low magnetic fields, they are less effective at high magnetic fields, and this is also the case of Gd-chelates and SPIONS. MRI scanners working at high magnetic fields (>7 T) are more and more demanded nowadays as they increase sensitivity and shorten acquisition times.2 Therefore, new CAs need to be developed to improve diagnostic capabilities of the new generation of high field MRI scanners. Dy3+ and Ho3+ are two ions that are suitable for high field T2 CAs due to their large magnetic moment without saturation of the magnetization at very high magnetic fields.3 The purpose of this work is to synthesize uniform, water dispersible LnF3 (Ln= Ho, Dy) nanoparticles, using homogeneous precipitation in polyol medium, and to evaluate their relaxivity at high magnetic field (9.4 T), to be used as MRI CAs in biomedicine. In addition, due to their high atomic number, these DyF3 and HoF3 nanoparticles show high X-ray attenuation capacity, which confer a double functionality to the probes, both as MRI and X-ray Computed Tomography CAs.
DescriptionResumen del trabajo presentado en NanoSpain Conference, celebrada en Barcelona (España), del 28 al 31 de mayo de 2019
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