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Synthesis of enantiomerically pure 1-amino-2-phenylcycloalkanecarboxylic acids (cnPhe)

AuthorsLasa, Marta; Cativiela, Carlos
KeywordsAmino acids
Asymmetric synthesis
Enantiomeric resolution
Issue Date2006
CitationSynlett (16): 2517-2533 (2006)
AbstractConstrained amino acids have become very important tools for modern drug discovery research. Phenylalanine is an ­appropriate residue for study, due to its participation in active site recognition. The series of 1-amino-2-phenylcycloalkanecarboxylic acids - cnPhe - constitutes an attractive family of constrained ­analogues of phenylalanine that can provide different orientations of the phenyl moiety. All stereoisomers of this series, from the ­cyclopropane to the cyclohexane members, are available in enantio­merically pure form.
Description17 pages.
Publisher version (URL)http://dx.doi.org/10.1055/s-2006-951468
Appears in Collections:(ICMA) Artículos
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