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Título: | Radio-enhancing properties of bimetallic Au:Pt nanoparticles: Experimental and theoretical evidence |
Autor: | Salado-Leza, Daniela; Traore, A. CSIC; Porcel, Erika; Dragoe, Diana; Muñoz, Antonio; Remita, Hynd; García, Gustavo CSIC ORCID; Lacombe, Sandrine | Palabras clave: | Core-shell gold–platinum nanoparticles Radio-enhancement Radiosensitization Complex damage Geant4-DNA Monte Carlo simulations |
Fecha de publicación: | 12-nov-2019 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | International Journal of Molecular Sciences 20(22): 5648 (2019) | Resumen: | The use of nanoparticles, in combination with ionizing radiation, is considered a promising method to improve the performance of radiation therapies. In this work, we engineered mono- and bimetallic core-shell gold–platinum nanoparticles (NPs) grafted with poly (ethylene glycol) (PEG). Their radio-enhancing properties were investigated using plasmids as bio-nanomolecular probes and gamma radiation. We found that the presence of bimetallic Au:Pt-PEG NPs increased by 90% the induction of double-strand breaks, the signature of nanosize biodamage, and the most difficult cell lesion to repair. The radio-enhancement of Au:Pt-PEG NPs were found three times higher than that of Au-PEG NPs. This effect was scavenged by 80% in the presence of dimethyl sulfoxide, demonstrating the major role of hydroxyl radicals in the damage induction. Geant4-DNA Monte Carlo simulations were used to elucidate the physical processes involved in the radio-enhancement. We predicted enhancement factors of 40% and 45% for the induction of nanosize damage, respectively, for mono- and bimetallic nanoparticles, which is attributed to secondary electron impact processes. This work contributed to a better understanding of the interplay between energy deposition and the induction of nanosize biomolecular damage, being Monte Carlo simulations a simple method to guide the synthesis of new radio-enhancing agents. | Versión del editor: | https://doi.org/10.3390/ijms20225648 | URI: | http://hdl.handle.net/10261/195371 | DOI: | 10.3390/ijms20225648 | E-ISSN: | 1422-0067 |
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radio-enhancing_properties_bimetallic_Au_Pt_nanoparticles.pdf | 2,9 MB | Adobe PDF | Visualizar/Abrir |
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