Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/195071
Share/Export:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Title

Preparation and characterization of a supramolecular hydrogel made of phospholipids and oleic acid with a high water content

AuthorsTalló, Kirian CSIC ORCID ; Bosch, Manel; Pons Pons, Ramon; Cocera Núñez, Mercedes CSIC ORCID; López Serrano, Olga CSIC ORCID
KeywordsSupramolecular hydrogel
Highly hydrated hydrogel
Issue Date18-Nov-2019
PublisherRoyal Society of Chemistry (UK)
CitationJournal of Materials Chemistry B 8(1),161-167 (2020)
AbstractA hydrogel formed with phospholipids and fatty acids would be of great interest in the medical field due to the biological relevance that these molecules have in living organisms. However, the tendency of phospholipid mixtures to form vesicular or micellar aggregates at high water content hinders the formation of this type of hydrogels. In this study, a highly hydrated hydrogel (95% water) was formed with hydrogenated phosphatidylcholine and oleic acid. The preparation method involved a freeze-heating cycle of the aqueous lipid mixture, favouring the supramolecular aggregation of these molecules into a microscopic spongey morphology. Confocal fluorescence imaging showed that the microstructure of the hydrogel is made from the aggregation of giant multilamellar vesicles (5-20 µm diameter) while transmission electron microscopy revealed the existence of nanosized unilamellar vesicles (150 nm diameter) coexisting with lipid lamellae. Despite this type of aggregation, X-ray scattering experiments performed on the hydrogel show almost no correlation between lipid membranes. In terms of rheological properties, the material shows a prevalent elastic behaviour and a low structural strength consequence of non-covalent interactions. With such properties and composition, this structured but easily deformable material might become a useful tool for biomedical applications.
Publisher version (URL)http://doi.org/10.1039/C9TB01599J
URIhttp://hdl.handle.net/10261/195071
DOI10.1039/C9TB01599J
ISSN2050-750X
E-ISSN2050-7518
Appears in Collections:(IQAC) Artículos

Files in This Item:
File Description SizeFormat
Preparation_characterization_supramolecular_hydrogel.pdfPublisher's version7,4 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work

WEB OF SCIENCETM
Citations

3
checked on Jan 23, 2022

Page view(s)

216
checked on Jan 25, 2022

Download(s)

76
checked on Jan 25, 2022

Google ScholarTM

Check

Altmetric

Dimensions


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.