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Galacto-oligosaccharides derived from lactulose protects against colorectal cancer development in a animal model

AuthorsFernández, Javier; Moreno, F. Javier ; Olano, Agustín ; Clemente, Alfonso; Villar, Claudio J.; Lombó, Felipe
Issue Date2018
Series9th Workshop SEPyP (2018)
Abstract[Introduction] Colorectal cancer has become one of the leading causes of cancer-related mortality worldwide; consequently, much attention has been focused on preventive and therapeutic strategies. In this sense, prebiotics have been reported as potential anti-inflammatory and anti-carcinogenic agents within the gastrointestinal tract. In this work, we have investigated the protective effect of novel galacto-oligosacharides derived from lactulose (GOS-Lu). These prebiotics have shown strong bifidogenic properties in vivo (Clemente et al., 2011; Hernández-Hernández et al., 2012).
[Objectives] GOS-Lu has been tested here as potential antitumor preventive prebiotic, in a rat model developed with azoxymethane (AOM) as chemical inducer of colorectal cancer.
[Methods] Male Fisher 344 rats were randomly assigned to two groups (n=10 per group, including 2 rats lacking colorectal cancer AOM induction): one cohort (negative control) with drinking water, and experimental cohort with 10% GOS-Lu (w/v) added to drinking water. Eight animals in each cohort received two doses of AOM (10 mg/kg) plus two treatments with DSS (3% and 2%). After 17 weeks, animals were sacrificed and colon tissues analyzed for number of tumors and tumor mucosa affected area.
[Results] Anatomical studies showed that caecum weight was enlarged a 35.2% on average (p<0.05) in experimental animals fed GOS-Lu. The number of colon tumors was decreased 57.5% on average (p<0.05) in prebiotic-fed animals. In addition, the tumor affected area in colon mucosa was reduced a 50.5% on average (p<0.05) in animals drinking GOS-Lu in water.
[Conclusions] These findings suggest that inclusion of the prebiotic preparation GOS-Lu might contribute to the prevention of this important neoplasia.
DescriptionResumen del trabajo presentado al IX Workshop on Probiotics, Prebiotics of the Spanish Society of Probiotics and Prebiotics (Sociedad Española de Probióticos y Prebióticos, SEPyP), celebrado en Zaragoza (España) del 15 al 16 de febrero de 2018.
Appears in Collections:(EEZ) Comunicaciones congresos
(CIAL) Comunicaciones congresos
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