The Buckwheat Iminosugar d‐Fagomine Attenuates Sucrose‐Induced Steatosis and Hypertension in Rats

Abstract

This study examines the long‐term functional effects of d‐fagomine on sucrose‐ induced factors of metabolic dysfunctions and explores possible molecular mechanisms behind its action.

Methods & results Wistar Kyoto (WKY) rats were fed a 35% sucrose solution with d‐fagomine (or not, for comparison) or mineral water (controls) for 24 weeks. We recorded: body weight; energy intake; glucose tolerance; plasma leptin concentration and lipid profile; populations of Bacteroidetes, Firmicutes, bacteroidales, clostridiales, enterobacteriales, and Escherichia coli in feces; blood pressure; urine uric acid and F2t isoprostanes (F2‐IsoPs); perigonadal fat deposition; and hepatic histology and diacylglycerols (DAGs) in liver and adipose tissue.