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Title

Synthesis, Monoamine Oxidase Inhibition and Computational Analysis of Diversely Substituted N-Propargylated-1,3,5-triazines

AuthorsChioua, Mourad ; González-Camuñas, A.; Catarozzo, M. T.; Alcaro, S.; Ortuso, F.; Yáñez, Matilde; Marco-Contelles, José
KeywordsSynthesis
1,3,5-triazines
N-propargyl amines
Monoamine oxidase enzyme inhibition
Computational analysis
Issue Date2019
PublisherWiley-VCH
CitationChemistrySelect 4: 8334-8337 (2019)
AbstractIn this work six diversely substituted N-propargylated-1,3,5-triazines have been designed, synthesized, and evaluated as monoamine oxidase (MAO) inhibitors. Very surprisingly, only 4,6-dichloro-N-(prop-2-yn-1-yl)-1,3,5-triazin-2-amine (1) showed modest, but selective MAO−B inhibition (IC=14.2 ± 0.7 μM), whose binding affinity has been investigated by computational analysis.
Publisher version (URL)http://dx.doi.org/10.1002/slct.201901271
URIhttp://hdl.handle.net/10261/194616
Identifiersdoi: 10.1002/slct.201901271
issn: 2365-6549
Appears in Collections:(IQOG) Artículos
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