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Title

Efficient synthesis of a new pipecolic acid analogue with a bicyclic structure

AuthorsCasabona, Diego; Cativiela, Carlos
KeywordsConstrained amino acid
Quaternary amino acid
Proline analogue
2,5-Ethanepipecolic acid
Chemoselective reduction
Issue Date16-Oct-2006
PublisherElsevier
CitationTetrahedron 62(42): 10000-10004 (2006)
AbstractThis report describes the synthesis of 2-azabicyclo[2.2.2]octane-1-carboxylic acid, a constrained pipecolic acid analogue. The route gives a very good total yield starting from cheap and readily available compounds and uses very easy reactions.
Description5 pages, 3 figures, scheme 1.
Publisher version (URL)http://dx.doi.org/10.1016/j.tet.2006.08.006
URIhttp://hdl.handle.net/10261/19413
DOI10.1016/j.tet.2006.08.006
ISSN0098-1354
Appears in Collections:(ICMA) Artículos
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