Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/193714
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Release of multifunctional peptides from kiwicha (Amaranthus caudatus) protein under in vitro gastrointestinal digestion |
Autor: | Vilcacundo, Rubén; Martínez-Villaluenga, Cristina CSIC ORCID ; Miralles, Beatriz CSIC ORCID ; Hernández-Ledesma, Blanca CSIC ORCID | Fecha de publicación: | 2019 | Editor: | John Wiley & Sons | Citación: | Journal of the Science of Food and Agriculture 99(3): 1225-1232 (2019) | Resumen: | [Background] The multifactorial origin of many chronic diseases provides a new framework for the development of multifunctional foods. In this study, the effect of in vitro simulated gastrointestinal digestion of kiwicha (Amaranthus caudatus) proteins on the release of multifunctional peptides was evaluated. [Results] Gastric digest showed higher angiotensin I converting enzyme (ACE) inhibitory activity while 60 min gastroduodenal digest showed the highest antioxidant, dipeptidyl peptidase IV (DPP‐IV), α‐amylase and Caco‐2 cell viability inhibitory activities. Peptides >5 kDa were more effective in inhibiting colon cancer cell viability, whereas peptides <5 kDa were mainly responsible for the antioxidant, ACE, DPP‐IV and α‐amylase inhibitory activities. Thirteen peptides from amaranth sequenced proteins were identified. Structure–activity relationship analysis of the identified sequences pointed to three amaranth fragments, namely FLISCLL, SVFDEELS and DFIILE, as potential peptides able to concurrently exert antioxidant capacity and ability to inhibit both ACE and α‐amylase. [Conclusion] Five of thirteen peptides identified in kiwicha protein digests show high potential to exert multifunctional properties. Thus kiwicha proteins might start to gain importance as ingredients for functional foods for the prevention and/or management of chronic diseases related to oxidative stress, hypertension and/or diabetes. |
Versión del editor: | https://doi.org/10.1002/jsfa.9294 | URI: | http://hdl.handle.net/10261/193714 | DOI: | 10.1002/jsfa.9294 | ISSN: | 0022-5142 | E-ISSN: | 1097-0010 |
Aparece en las colecciones: | (ICTAN) Artículos (CIAL) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
releasediges.pdf | 305,36 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
13
checked on 11-mar-2024
SCOPUSTM
Citations
45
checked on 16-abr-2024
WEB OF SCIENCETM
Citations
33
checked on 22-feb-2024
Page view(s)
205
checked on 19-abr-2024
Download(s)
663
checked on 19-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.